Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors. (Q34101852)

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7 February 2020

title

Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors (English)

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Alessio Lodola

6

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7 February 2020

Federica Vacondio

7

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Marco Mor

10

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Andrea Duranti

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Andrea Tontini

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Giorgio Tarzia

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7 February 2020

author name string

Carlos Solorzano

1

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Francesca Antonietti

2

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Daniele Piomelli

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language of work or name

English

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publication date

1 August 2010

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Journal of Medicinal Chemistry

7 February 2020

published in

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volume

53

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issue

15

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page(s)

5770-5781

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N-palmitoyl-ethanolamine: Biochemistry and new therapeutic opportunities

7 February 2020

cites work

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Synthesis and biological evaluation of new potential inhibitors of N-acylethanolamine hydrolyzing acid amidase

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Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.

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The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors

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The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

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Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases

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Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site

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Conjugated bile acid hydrolase is a tetrameric N-terminal thiol hydrolase with specific recognition of its cholyl but not of its tauryl product.

5 July 2018

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Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase

5 July 2018

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The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide.

5 July 2018

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N-cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolysing N-acylethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase

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5 July 2018

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Amino acid residues crucial in pH regulation and proteolytic activation of N-acylethanolamine-hydrolyzing acid amidase

28 October 2018

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28 October 2018

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28 October 2018

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28 October 2018

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Esters, Retroesters, and a Retroamide of Palmitic Acid: Pool for the First Selective Inhibitors of N-Palmitoylethanolamine- Selective Acid Amidase

28 October 2018

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28 October 2018

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28 October 2018

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28 October 2018

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Purification and characterization of an acid amidase selective for N-palmitoylethanolamine, a putative endogenous anti-inflammatory substance

28 October 2018

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28 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20604568

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

STUDIES ON POLYPEPTIDES. XXIX. SYNTHETIC PEPTIDES RELATED TO THE N-TERMINUS OF BOVINE PANCREATIC RIBONUCLEASE A (POSITIONS 1-7)

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20604568

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM100582W

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20604568%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20604568%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference