Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart (Q34102948)

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English	Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

31 July 2017

Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart (English)

1 reference

Europe PubMed Central

31 July 2017

author name string

Luis A Gómez

1

1 reference

Europe PubMed Central

31 July 2017

Shi-Hua D Heath

2

1 reference

Europe PubMed Central

31 July 2017

Tory M Hagen

3

1 reference

Europe PubMed Central

31 July 2017

publication date

1 February 2012

1 reference

Europe PubMed Central

31 July 2017

Mechanisms of Ageing and Development

1 reference

Europe PubMed Central

31 July 2017

133

1 reference

Europe PubMed Central

31 July 2017

2-3

1 reference

Europe PubMed Central

31 July 2017

99-106

1 reference

Europe PubMed Central

31 July 2017

Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

1 reference

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Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: role of hormesis and vitagenes

1 reference

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Acetyl-L-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain

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1 reference

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Shedding light on the enigma of myocardial lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization.

1 reference

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Lipotoxicity in the heart

1 reference

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Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction.

1 reference

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Changes in lipid distribution during aging and its modulation by calorie restriction

1 reference

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Accumulation of overoxidized Peroxiredoxin III in aged rat liver mitochondria

1 reference

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Cardiac mitochondrial bioenergetics, oxidative stress, and aging

1 reference

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Lipotoxicity, overnutrition and energy metabolism in aging

1 reference

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Antioxidant effect of L-carnitine and its short chain esters: relevance for the protection from oxidative stress related cardiovascular damage

1 reference

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Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity

1 reference

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Mitochondrial beta-oxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

5 July 2018

Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

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Regulation of myocardial triacylglycerol synthesis and metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

5 July 2018

Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

5 July 2018

Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

5 July 2018

Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

5 July 2018

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

5 July 2018

Age and sex dependency of carnitine concentration in human serum and skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

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Mitochondrial dysfunction in cardiac disease: ischemia--reperfusion, aging, and heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

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Molecular enzymology of carnitine transfer and transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

5 July 2018

Regulation by carnitine of myocardial fatty acid and carbohydrate metabolism under normal and pathological conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

5 July 2018

Aging selectively decreases oxidative capacity in rat heart interfibrillar mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

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Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

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The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

5 July 2018

Carnitine palmitoyl transferase-I activity in the aging mouse heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

5 July 2018

Role of carnitine palmitoyltransferase I in the regulation of hepatic ketogenesis during the onset and reversal of chronic diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

5 July 2018

Levels of carnitines in brain and other tissues of rats of different ages: effect of acetyl-L-carnitine administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

5 July 2018

Fatty acid oxidation by isolated perfused working hearts of aged rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

5 July 2018

Acetyl-L-carnitine supplementation to old rats partially reverts the age-related mitochondrial decay of soleus muscle by activating peroxisome proliferator-activated receptor gamma coactivator-1alpha-dependent mitochondrial biogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

28 October 2018

Functional effects of protein kinases and peroxynitrite on cardiac carnitine palmitoyltransferase-1 in isolated mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

28 October 2018

CD36 expression contributes to age-induced cardiomyopathy in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

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Protective role of carnitine ester against radiation-induced oxidative stress in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

28 October 2018

Proteomics analyses of specific protein oxidation and protein expression in aged rat brain and its modulation by L-acetylcarnitine: insights into the mechanisms of action of this proposed therapeutic agent for CNS disorders associated with oxidative

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

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Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

28 October 2018

Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

28 October 2018

Acetyl-L-carnitine supplementation restores decreased tissue carnitine levels and impaired lipid metabolism in aged rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

28 October 2018

Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

28 October 2018

Functional and structural basis of carnitine palmitoyltransferase 1A deficiency.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

28 October 2018

Impact of aging on substrate metabolism by the human heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

28 October 2018

Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

28 October 2018

Energetic crosstalk between organelles: architectural integration of energy production and utilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

28 October 2018

ATP consumption by uncoupled mitochondria activates sarcolemmal K(ATP) channels in cardiac myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

28 October 2018

Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

28 October 2018

Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tert-butyl-alpha-phenyl-nitrone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

28 October 2018

Restoration of the properties of carnitine palmitoyltransferase I in liver mitochondria during re-feeding of starved rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4147858

28 October 2018

Mitochondrial metabolism and substrate competition in the aging Fischer rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of aging and acetyl-L-carnitine on the pyruvate transport and oxidation in rat heart mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging decreases electron transport complex III activity in heart interfibrillar mitochondria by alteration of the cytochrome c binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum carnitine concentrations in patients with idiopathic hypertrophic cardiomyopathy: relationship with impaired myocardial fatty acid metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hamster cardiomyopathy. A defect in oxidative phosphorylation in the cardiac interfibrillar mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ischemic injury to mitochondrial electron transport in the aging heart: damage to the iron-sulfur protein subunit of electron transport complex III

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent decrease of carnitine content in muscle of mice and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetyl-L-carnitine feeding to unloaded rats triggers in soleus muscle the coordinated expression of genes involved in mitochondrial biogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnitine determination by an enzymatic cycling method with carnitine dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of carnitine feeding on the levels of heart and skeletal muscle carnitine of elderly mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related changes in the activity of the pyruvate carrier and in the lipid composition in rat-heart mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural differences in two biochemically defined populations of cardiac mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnitine-acylcarnitine translocase activity in cardiac mitochondria from aged rats: the effect of acetyl-L-carnitine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-linked changes in the activity of enzymes of the tricarboxylate cycle and lipid oxidation, and of carnitine content, in muscles of the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat liver mitochondrial proteome: Changes associated with aging and acetyl-L-carnitine treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of aging and acetyl-L-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22322067

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.MAD.2012.01.007

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

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