The RET proto-oncogene in human cancers (Q34103632)

31 July 2017

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title

The RET proto-oncogene in human cancers (English)

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31 July 2017

Jhiang SM

1

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PubMed ID

11114739

31 July 2017

language of work or name

English

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publication date

1 November 2000

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31 July 2017

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31 July 2017

19

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31 July 2017

49

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31 July 2017

5590-5597

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203857

31 July 2017

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cites work

Multiple endocrine neoplasia type 2B mutation in human RET oncogene induces medullary thyroid carcinoma in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

GDNF family neurotrophic factor signaling: four masters, one servant?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Mechanism of Ret activation by a mutation at aspartic acid 631 identified in sporadic pheochromocytoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

The GDNF family ligands and receptors - implications for neural development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

A RET double mutation in the germline of a kindred with FMTC.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

A potential pathogenetic mechanism for multiple endocrine neoplasia type 2 syndromes involves ret-induced impairment of terminal differentiation of neuroepithelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Signaling through Ras is essential for ret oncogene-induced cell differentiation in PC12 cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Early cellular abnormalities induced by RET/PTC1 oncogene in thyroid-targeted transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

RET rearrangements in papillary thyroid carcinomas and adenomas detected by interphase FISH

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Abrogation of nerve growth factor-induced terminal differentiation by ret oncogene involves perturbation of nuclear translocation of ERK

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Shc and Enigma are both required for mitogenic signaling by Ret/ptc2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

RET proto-oncogene in the development of human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Papillary thyroid carcinoma oncogene (RET/PTC) alters the nuclear envelope and chromatin structure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

A two-hit model for development of multiple endocrine neoplasia type 2B by RET mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

RET is expressed but not mutated in extra-adrenal paragangliomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Development of medullary thyroid carcinoma in transgenic mice expressing the RET protooncogene altered by a multiple endocrine neoplasia type 2A mutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Preferential induction of RET/PTC1 rearrangement by X-ray irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Oncogenic activation of RET by two distinct FMTC mutations affecting the tyrosine kinase domain.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Signaling through scaffold, anchoring, and adaptor proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Different mutations of the RET gene cause different human tumoral diseases.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Growth factor signaling by receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Distinct frequency of ret rearrangements in papillary thyroid carcinomas of children and adults from Belarus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Sporadic ret-rearranged papillary carcinoma of the thyroid: a subset of slow growing, less aggressive thyroid neoplasms?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Somatic mutations in RET exons 12 and 15 in sporadic medullary thyroid carcinomas: different spectrum of mutations in sporadic type from hereditary type.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret and FGF receptor tyrosine kinase activation is correlated with sustained ERK2 activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Signal transduction by the receptor tyrosine kinase Ret.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Signal transduction pathways activated by RET oncoproteins in PC12 pheochromocytoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Characterization of ret oncogenic activation in MEN2 inherited cancer syndromes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203857

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203857

1 reference

PubMed ID

11114739

Dimensions Publication ID

31 July 2017

0 references

1 reference

PubMed ID

11114739