Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions (Q34107486)

31 July 2017

title

Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions (English)

1 reference

31 July 2017

Zhaobing Gao

1

1 reference

31 July 2017

Tangzhi Zhang

2

1 reference

31 July 2017

Meng Wu

3

1 reference

31 July 2017

Qiaojie Xiong

4

1 reference

31 July 2017

Haiyan Sun

5

1 reference

31 July 2017

Yinan Zhang

6

1 reference

31 July 2017

Liansuo Zu

7

1 reference

31 July 2017

Wei Wang

8

1 reference

31 July 2017

Min Li

9

1 reference

31 July 2017

language of work or name

English

0 references

publication date

28 June 2010

1 reference

Journal of Biological Chemistry

31 July 2017

published in

1 reference

31 July 2017

volume

285

1 reference

31 July 2017

issue

36

1 reference

31 July 2017

page(s)

28322-28332

1 reference

Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Fluorine in pharmaceuticals: looking beyond intuition

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

5 July 2018

From molecule to malady

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Modulation of potassium channels as a therapeutic approach.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Chronic inhibition of cardiac Kir2.1 and HERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Differential roles of S6 domain hinges in the gating of KCNQ potassium channels.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

A potassium channel, the M-channel, as a therapeutic target

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Function recovery after chemobleaching (FRAC): evidence for activity silent membrane receptors on cell surface

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Structural changes during ion channel gating

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

The open pore conformation of potassium channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Crystal structure and mechanism of a calcium-gated potassium channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Ion-channel assay technologies: quo vadis?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

KCNQ2/KCNQ3 K+ channels and the molecular pathogenesis of epilepsy: implications for therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the cognitive enhancer XE991.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Voltage-Dependent Gating of Ionic Channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Voltage gating of ion channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

A manual method for applying the Hansch approach to drug design

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models

5 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.116392

Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.116392

KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.116392

The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.116392

Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.116392

Utilization of operational schemes for analog synthesis in drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.116392

Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.116392

The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.116392

Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934696

Kv7 (KCNQ) potassium channels that are mutated in human diseases

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20584905

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Functional analysis of native and recombinant ion channels using a high-capacity nonradioactive rubidium efflux assay

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20584905

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A maxi calcium-activated potassium channel from chick lens epithelium

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20584905

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.116392

1 reference

31 July 2017

1 reference

31 July 2017

1 reference