A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. (Q34108567)

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English	A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.	scientific article

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scholarly article

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5 February 2020

A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B (English)

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5 February 2020

Candida albicans

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Josie E. Parker

2

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5 February 2020

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5 February 2020

Andrew Warrilow

6

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5 February 2020

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Claire M Martel

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5 February 2020

Michael Weig

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5 February 2020

Uwe Gross

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5 February 2020

Diane E Kelly

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5 February 2020

Steven L Kelly

8

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5 February 2020

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14 June 2010

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5 February 2020

Antimicrobial Agents and Chemotherapy

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5 February 2020

54

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5 February 2020

3578-3583

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5 February 2020

9

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5 February 2020

In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods

1 reference

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5 July 2018

Evaluation of amphotericin B interpretive breakpoints for Candida bloodstream isolates by correlation with therapeutic outcome

1 reference

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5 July 2018

Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance

1 reference

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5 July 2018

Inactivation of sterol Delta5,6-desaturase attenuates virulence in Candida albicans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934972

5 July 2018

Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance

1 reference

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5 July 2018

Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans

1 reference

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5 July 2018

Lipid raft polarization contributes to hyphal growth in Candida albicans

1 reference

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5 July 2018

Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection

1 reference

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5 July 2018

Molecular aspects of azole antifungal action and resistance

1 reference

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5 July 2018

Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934972

5 July 2018

Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934972

5 July 2018

The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14alpha demethylase in Candida albicans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934972

5 July 2018

Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934972

5 July 2018

Isolation and characterization of fluconazole- and amphotericin B-resistant Candida albicans from blood of two patients with leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934972

5 July 2018

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934972

5 July 2018

Defective sterol C5-6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934972

5 July 2018

Fluconazole modulates membrane rigidity, heterogeneity, and water penetration into the plasma membrane in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934972

28 October 2018

A phase II randomized trial of amphotericin B alone or combined with fluconazole in the treatment of HIV-associated cryptococcal meningitis.

1 reference

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28 October 2018

Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus

1 reference

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28 October 2018

Susceptibility of clinical isolates of Candida species to fluconazole and detection of Candida albicans ERG11 mutations

1 reference

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28 October 2018

A novel mechanism of fluconazole resistance associated with fluconazole sequestration in Candida albicans isolates from a myelofibrosis patient

1 reference

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28 October 2018

Matrix polymers of Candida biofilms and their possible role in biofilm resistance to antifungal agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934972

28 October 2018

Characteristics of the heterologously expressed human lanosterol 14alpha-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and Candida albicans CYP51 with azole antifungal agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934972

28 October 2018

Synergic effects of tactolimus and azole antifungal agents against azole-resistant Candida albican strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/20547793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta5,6-desaturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20547793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mutation T315A in Candida albicans sterol 14alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20547793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to fluconazole in Candida albicans from AIDS patients correlated with reduced intracellular accumulation of drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/20547793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20547793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20547793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular analysis of cyp51 from fluconazole-resistant Candida albicans strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/20547793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of Saccharomyces cerevisiae CYP61, sterol delta22-desaturase, and inhibition by azole antifungal agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/20547793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sterol 22-desaturase, cytochrome P45061, possesses activity in xenobiotic metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20547793

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.00303-10

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5 February 2020

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24 November 2022

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5 February 2020

1 reference

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5 February 2020

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