The Th1/Th2 paradigm in the pathogenesis of scleroderma, and its modulation by thalidomide (Q34109142)

31 July 2017

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title

The Th1/Th2 paradigm in the pathogenesis of scleroderma, and its modulation by thalidomide (English)

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31 July 2017

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Oliver SJ

1

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31 July 2017

publication date

1 December 2000

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Current Rheumatology Reports

31 July 2017

published in

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31 July 2017

volume

2

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31 July 2017

issue

6

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31 July 2017

page(s)

486-491

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Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy

31 July 2017

cites work

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https://api.crossref.org/works/10.1007%2FS11926-000-0025-7

Schistosome infections in humans: perspectives and recent findings. NIH conference

21 January 2018

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Scleroderma, Sjögren-like Syndrome, and Chronic Graft-Versus-Host Disease

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Thalidomide in the treatment of the mucocutaneous lesions of the Behçet syndrome. A randomized, double-blind, placebo-controlled trial

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Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells

21 January 2018

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12 December 2020

Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

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12 December 2020

Leukocytes Of Patients With Schistosoma Mansoni Respond With A Th2 Pattern Of Cytokine Production To Mitogen Or Egg Antigens But With A Th0 Pattern To Worm Antigens

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12 December 2020

Interferon-alpha and interferon-gamma reduce excessive collagen synthesis and procollagen mRNA levels of scleroderma fibroblasts in culture

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12 December 2020

Thalidomide for the treatment of oral aphthous ulcers in patients with human immunodeficiency virus infection. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group.

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12 December 2020

Pathophysiology of the inflammatory response

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12 December 2020

Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset

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12 December 2020

Direct contact between T lymphocytes and human dermal fibroblasts or synoviocytes down-regulates types I and III collagen production via cell-associated cytokines.

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12 December 2020

Circulating levels of soluble CD30 are increased in patients with systemic sclerosis (SSc) and correlate with serological and clinical features of the disease

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12 December 2020

Scleroderma-like changes due to chronic graft-versus-host disease

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12 December 2020

Gamma-interferon treatment inhibits collagen deposition in murine schistosomiasis.

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12 December 2020

Interferon gamma-1b for the treatment of idiopathic pulmonary fibrosis

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12 December 2020

The regulation of immunity to Leishmania major

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12 December 2020

Recalcitrant pyoderma gangrenosum: treatment with thalidomide

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12 December 2020

Thalidomide for the treatment of chronic graft-versus-host disease

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12 December 2020

Eosinophil activation in systemic sclerosis

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12 December 2020

Treatment of fistulas with granulocyte colony-stimulating factor in a patient with Crohn's disease

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12 December 2020

Lymphokine-activated killer cell and natural killer cell activities in patients with systemic sclerosis

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12 December 2020

Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis.

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12 December 2020

Successful treatment of aphthous ulcerations in AIDS patients using topical granulocyte-macrophage colony-stimulating factor

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12 December 2020

Interferon-gamma in the treatment of systemic sclerosis: a randomized controlled multicentre trial.

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12 December 2020

Tight-Skin Mouse an Experimental Model for Scleroderma

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12 December 2020

Thalidomide-induced antigen-specific immune stimulation in patients with human immunodeficiency virus type 1 and tuberculosis.

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12 December 2020

Cytokine production and serum levels in systemic sclerosis

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12 December 2020

Paradoxical effect of thalidomide prophylaxis on chronic graft-vs.-host disease

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12 December 2020

Interleukin-4 stimulates collagen synthesis by normal and scleroderma fibroblasts in dermal equivalents

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12 December 2020

Suppressor cell function and t lymphocyte subpopulations in peripheral blood of patients with progressive systemic sclerosis

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12 December 2020

Steady-state mRNA levels of collagens I, III, fibronectin, and collagenase in skin biopsies of systemic sclerosis patients

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12 December 2020

Thalidomide treatment reduces tumor necrosis factor alpha production and enhances weight gain in patients with pulmonary tuberculosis

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12 December 2020

Microchimerism and the pathogenesis of systemic sclerosis

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12 December 2020

Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni

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12 December 2020

Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4

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12 December 2020

Human Basophil Releasability. VIII. Increased Basophil Releasability in Patients with Scleroderma

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12 December 2020

Dermal mast cell degranulation in systemic sclerosis

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12 December 2020

Systemic scleroderma. Multicenter trial of 1 year of treatment with recombinant interferon gamma

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12 December 2020

The expanding universe of T-cell subsets: Th1, Th2 and more.

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12 December 2020

Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12.

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12 December 2020

Interleukin-12 inhibits murine graft-versus-host disease

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12 December 2020

Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis

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12 December 2020

Recombinant cytokine treatment for scleroderma. Can the antifibrotic potential of interferon-gamma be realized clinically?

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12 December 2020

Histopathologic differentiation between localized and systemic scleroderma

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12 December 2020

Anti-IL-4 treatment prevents dermal collagen deposition in the tight-skin mouse model of scleroderma

1 reference

12 December 2020

Thalidomide stimulates T cell responses and interleukin 12 production in HIV-infected patients.

1 reference

12 December 2020

Interleukin-1, Interleukin-2, Interleukin-4, Interleukin-6, Tumor Necrosis Factor α, and Interferon-γ Levels in Sera from Patients With Scleroderma

1 reference

12 December 2020

Treatment and prevention of acute graft-versus-host disease with thalidomide in a rat model

1 reference

12 December 2020

Th1-Th2 paradigm: insights from leprosy

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12 December 2020

Enhanced Th1 and dampened Th2 responses synergize to inhibit acute granulomatous and fibrotic responses in murine schistosomiasis mansoni.

1 reference

12 December 2020

Selective inhibition of human diploid fibroblast collagen synthesis by interferons

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12 December 2020

Type 2 helper T-cell predominance and high CD30 expression in systemic sclerosis.

1 reference

12 December 2020

Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha

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12 December 2020

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4.

1 reference

12 December 2020

Therapy of chronic graft-v-host disease in a rat model

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12 December 2020

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

1 reference

12 December 2020

Lymphocytes in the skin of patients with progressive systemic sclerosis. Quantification, subtyping, and clinical correlations

1 reference

12 December 2020

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

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12 December 2020

Antagonistic effects of interferon-gamma and interleukin-4 on fibroblast cultures

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12 December 2020

Mononuclear cellular infiltrates in clinically involved skin from patients with systemic sclerosis of recent onset predominantly consist of monocytes/macrophages

1 reference

12 December 2020

IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia.

1 reference

12 December 2020

Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast

1 reference

12 December 2020

Immunochemotherapy for a systemic intracellular infection: accelerated response using interferon-gamma in visceral leishmaniasis

1 reference

12 December 2020

Gamma interferon is the lymphokine and beta interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation

1 reference

12 December 2020

A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice

1 reference

12 December 2020

Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton

1 reference

12 December 2020

10.1007/S11926-000-0025-7

Identifiers

DOI

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Dimensions Publication ID

31 July 2017

1009790998

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