Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca (Q34110644)

31 July 2017

Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca (English)

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keratoconjunctivitis sicca

31 July 2017

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Cintia S De Paiva

1

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author name string

Eugene A Volpe

2

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31 July 2017

Niral B Gandhi

3

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31 July 2017

Xiaobo Zhang

4

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31 July 2017

Xiaofen Zheng

5

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31 July 2017

John D Pitcher

6

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31 July 2017

William J Farley

7

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31 July 2017

Michael E Stern

8

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31 July 2017

Jerry Y Niederkorn

9

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31 July 2017

De-Quan Li

10

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31 July 2017

Richard A Flavell

11

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31 July 2017

Stephen C Pflugfelder

12

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31 July 2017

language of work or name

English

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publication date

14 December 2011

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31 July 2017

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31 July 2017

6

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31 July 2017

12

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31 July 2017

e29017

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Creative Commons Attribution 4.0 International

31 July 2017

start time

14 December 2011

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Desiccating stress induces CD4+ T-cell-mediated Sjögren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-γ

5 July 2018

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Interferon-γ exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways.

5 July 2018

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Spontaneous autoimmune dacryoadenitis in aged CD25KO mice

5 July 2018

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Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay

5 July 2018

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Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress

5 July 2018

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5 July 2018

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Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice

5 July 2018

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Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome

5 July 2018

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IL-17 disrupts corneal barrier following desiccating stress.

5 July 2018

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Both Th1 and Th17 are immunopathogenic but differ in other key biological activities

5 July 2018

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'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation

5 July 2018

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T(H)-17 cells in the circle of immunity and autoimmunity

5 July 2018

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Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice

5 July 2018

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Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline

5 July 2018

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

5 July 2018

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Transforming growth factor-beta induces development of the T(H)17 lineage

5 July 2018

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Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye.

5 July 2018

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Transforming growth factor-beta regulation of immune responses

5 July 2018

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

5 July 2018

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T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells

5 July 2018

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Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye

5 July 2018

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Pathogenesis of Sjögren's syndrome: characteristics of different mouse models for autoimmune exocrinopathy

5 July 2018

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Lacrimal gland inflammation is responsible for ocular pathology in TGF-beta 1 null mice

5 July 2018

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Transforming growth factor beta-1 and beta-2 in human tear fluid

5 July 2018

1 reference

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Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

5 July 2018

1 reference

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Eyelid reconstruction with hard palate mucosa grafts

5 July 2018

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Differential cytokine mRNA expression in human labial minor salivary glands in primary Sjögren's syndrome

5 July 2018

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Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease.

21 January 2018

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Modulation of integrin alpha4beta1 (VLA-4) in dry eye disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0029017

Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium.

21 January 2018

1 reference

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The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut.

21 January 2018

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Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0029017

Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0029017

Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease

21 January 2018

1 reference

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Autoimmune Sjögren's-like lesions in salivary glands of TGF-beta1-deficient mice are inhibited by adhesion-blocking peptides.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237576

Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca

28 October 2018

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12 December 2020

Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands

1 reference

12 December 2020

Desiccating Stress Induces T Cell-Mediated Sjogren's Syndrome-Like Lacrimal Keratoconjunctivitis

1 reference

12 December 2020

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

1 reference

12 December 2020

Production and secretion of transforming growth factor beta (TGF-beta) by the human lacrimal gland

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0029017

Identifiers

DOI

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31 July 2017

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31 July 2017

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