Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy. (Q34112939)

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6 February 2020

title

Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy (English)

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6 February 2020

7

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6 February 2020

author name string

J Schlichtiger

1

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6 February 2020

A Pekcec

2

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6 February 2020

H Bartmann

3

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6 February 2020

P Winter

4

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6 February 2020

C Fuest

5

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6 February 2020

J Soerensen

6

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6 February 2020

language of work or name

English

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publication date

1 July 2010

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British Journal of Pharmacology

6 February 2020

published in

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volume

160

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6 February 2020

issue

5

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6 February 2020

page(s)

1062-1071

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Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation

6 February 2020

cites work

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5 July 2018

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Several major antiepileptic drugs are substrates for human P-glycoprotein

5 July 2018

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The role of ATP binding cassette transporters in tissue defense and organ regeneration.

5 July 2018

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Targeting epileptogenesis-associated induction of neurogenesis by enzymatic depolysialylation of NCAM counteracts spatial learning dysfunction but fails to impact epilepsy development

5 July 2018

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Molecular and cellular mechanisms of pharmacoresistance in epilepsy

5 July 2018

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Brain inflammation in epilepsy: experimental and clinical evidence

5 July 2018

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Drug resistance in brain diseases and the role of drug efflux transporters.

5 July 2018

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Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

5 July 2018

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Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

5 July 2018

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Modification of seizure activity by electrical stimulation. II. Motor seizure

5 July 2018

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Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling

5 July 2018

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Resistance to phenobarbital extends to phenytoin in a rat model of temporal lobe epilepsy

21 January 2018

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Effect of pantoprazole administered subcutaneously on the healing of sutured gastric incisions in rats

21 January 2018

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The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy

21 January 2018

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Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: concomitant use of hippocampal monoamines as pharmacodynamic markers for the anticonvulsant activity

21 January 2018

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Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil

21 January 2018

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P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats

21 January 2018

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Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy

21 January 2018

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Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats

21 January 2018

1 reference

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COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

21 January 2018

1 reference

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Multidrug resistance in epilepsy: rats with drug-resistant seizures exhibit enhanced brain expression of P-glycoprotein compared with rats with drug-responsive seizures.

21 January 2018

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Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures.

21 January 2018

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Increased expression of the multidrug transporter P-glycoprotein in limbic brain regions after amygdala-kindled seizures in rats

21 January 2018

1 reference

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Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables

21 January 2018

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Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition

21 January 2018

1 reference

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10.1111/J.1476-5381.2010.00765.X

21 January 2018

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590600%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

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6 February 2020

PubMed publication ID

20590600

1 reference