Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated [...] (Q34113009)

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English	Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated [...]	scientific article

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6 February 2020

Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/activator protein-1 (English)

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6 February 2020

extracellular matrix

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Hye Gwang Jeong

2

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6 February 2020

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Yong P Hwang

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6 February 2020

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1 July 2010

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6 February 2020

British Journal of Pharmacology

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6 February 2020

160

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6 February 2020

5

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6 February 2020

1195-1211

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6 February 2020

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

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Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival

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CaM kinase II delta2-dependent regulation of vascular smooth muscle cell polarization and migration

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5 July 2018

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model

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The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

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Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

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Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis.

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EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathways.

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5 July 2018

PMA-induced up-regulation of MMP-9 is regulated by a PKCalpha-NF-kappaB cascade in human lung epithelial cells

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5 July 2018

Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells

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5 July 2018

Regulation of matrix metalloproteinase gene expression

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5 July 2018

Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms

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5 July 2018

Characterization of Ca2+ interactions with matrix metallopeptidase-12: implications for matrix metallopeptidase regulation.

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Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis

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5 July 2018

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

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5 July 2018

Metformin and reduced risk of cancer in diabetic patients

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5 July 2018

Delayed and sustained activation of extracellular signal-regulated kinase in human keratinocytes by UVA: implications in carcinogenesis

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5 July 2018

From chemoprevention to chemotherapy: common targets and common goals

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5 July 2018

AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells

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5 July 2018

Calcium-induced matrix metalloproteinase 9 gene expression is differentially regulated by ERK1/2 and p38 MAPK in oral keratinocytes and oral squamous cell carcinoma

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5 July 2018

Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction

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5 July 2018

Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.

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5 July 2018

Glucocorticoid-mediated suppression of cytokine-induced matrix metalloproteinase-9 expression in rat mesangial cells: involvement of nuclear factor-kappaB and Ets transcription factors

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5 July 2018

Role of AMP-activated protein kinase in mechanism of metformin action

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5 July 2018

Structure and regulation of voltage-gated Ca2+ channels

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5 July 2018

Matrix metalloproteinases: multifunctional contributors to tumor progression

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5 July 2018

Cyclic nucleotide phosphodiesterases and human arterial smooth muscle cell proliferation.

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5 July 2018

The Ca-calmodulin-dependent protein kinase cascade

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5 July 2018

Regulation of matrix metalloproteinase expression in tumor invasion.

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5 July 2018

Distinct PKC isoforms mediate the activation of cPLA2 and adenylyl cyclase by phorbol ester in RAW264.7 macrophages

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5 July 2018

Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion

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5 July 2018

Modulation of intracellular calcium levels inhibits secretion of collagenase 1 by migrating keratinocytes

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5 July 2018

Effects of metformin on tyrosine kinase activity, glucose transport, and intracellular calcium in rat vascular smooth muscle

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5 July 2018

Expression of matrix metalloproteinase-2 and -9 during early human wound healing

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5 July 2018

Metformin Attenuates Agonist-Stimulated Calcium Transients in Vascular Smooth Muscle Cells

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5 July 2018

Calmodulin Plays a Pivotal Role in Cellular Regulation

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5 July 2018

Calmodulin: a potential target for cancer chemotherapeutic agents

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5 July 2018

Calcium/calmodulin-dependent protein kinase II.

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Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

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Tamoxifen-resistant human breast cancer cell growth: inhibition by thioridazine, pimozide and the calmodulin antagonist, W-13.

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Ca2+/calmodulin-regulated nitric oxide synthases

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5 July 2018

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Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286.

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21 January 2018

A novel mechanism of matrix metalloproteinase-9 gene expression implies a role for keratinization

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21 January 2018

AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells

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21 January 2018

Prevention of pancreatic cancer induction in hamsters by metformin

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21 January 2018

Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma

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21 January 2018

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28 October 2018

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28 October 2018

Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2.

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28 October 2018

5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation

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21 January 2018

Purification and characterization of bovine cardiac calmodulin-dependent myosin light chain kinase

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12 December 2020

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Positive correlation between calmodulin content and hepatoma growth rates

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12 December 2020

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Fusion of intracellular membrane pools with cell surfaces of macrophages stimulated by phorbol esters and calcium ionophores

1 reference

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12 December 2020

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Successful chemotherapy of experimental neuroendocrine lung tumors in hamsters with an antagonist of Ca2+/calmodulin

1 reference

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12 December 2020

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Calcium influx modulates expression of matrix metalloproteinase-2 (72-kDa type IV collagenase, gelatinase A)

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20590612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20590612

12 December 2020

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Quantitation of dihydropyrimidine dehydrogenase expression by real-time reverse transcription polymerase chain reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20590612

12 December 2020

based on heuristic

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Identifiers

10.1111/J.1476-5381.2010.00762.X

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590612%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590612%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590612%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

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