Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation. (Q34118639)

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English	Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation.	scientific article

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2 February 2020

Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation (English)

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Thomas J Santangelo

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Stefan Rothenburg

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Madhusudan Dey

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Frank Sicheri

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John N Reeve

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Alan G Hinnebusch

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17 July 2009

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2 February 2020

Journal of Molecular Biology

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701-722

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2 February 2020

Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: varying the number of double-stranded RNA binding domains and lineage-specific duplications

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28 July 2018

Polarity in archaeal operon transcription in Thermococcus kodakaraensis

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28 July 2018

Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states

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28 July 2018

Clustal W and Clustal X version 2.0

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28 July 2018

New insights into the interactions of the translation initiation factor 2 from archaea with guanine nucleotides and initiator tRNA

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28 July 2018

TFB1 or TFB2 is sufficient for Thermococcus kodakaraensis viability and for basal transcription in vitro

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28 July 2018

Translation initiation: structures, mechanisms and evolution

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28 July 2018

Translational regulation of GCN4 and the general amino acid control of yeast

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28 July 2018

ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures

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28 July 2018

PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha

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28 July 2018

The archaeal eIF2 homologue: functional properties of an ancient translation initiation factor

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28 July 2018

Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits

1 reference

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28 July 2018

Bacterial variations on the methionine salvage pathway

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28 July 2018

Characterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiation

1 reference

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28 July 2018

Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha

1 reference

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28 July 2018

Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation

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28 July 2018

Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.

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28 July 2018

Genomic evidence for two functionally distinct gene classes.

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28 July 2018

Regulation of guanine nucleotide exchange through phosphorylation of eukaryotic initiation factor eIF2alpha. Role of the alpha- and delta-subunits of eiF2b

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28 July 2018

Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells

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28 July 2018

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937263

28 July 2018

Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2

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28 July 2018

Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by analysis of conserved sequence motifs

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28 July 2018

A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast

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28 July 2018

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28 July 2018

Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes

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28 July 2018

Multiple GCD genes required for repression of GCN4, a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae

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28 July 2018

Molecular analysis of GCN3, a translational activator of GCN4: evidence for posttranslational control of GCN3 regulatory function

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28 July 2018

The translational activator GCN3 functions downstream from GCN1 and GCN2 in the regulatory pathway that couples GCN4 expression to amino acid availability in Saccharomyces cerevisiae.

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28 July 2018

Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya

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28 July 2018

Complex formation by positive and negative translational regulators of GCN4.

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28 July 2018

Archaeal type III RuBisCOs function in a pathway for AMP metabolism.

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Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B

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Crystal structure of the regulatory subunit of archaeal initiation factor 2B (aIF2B) from hyperthermophilic archaeon Pyrococcus horikoshii OT3: a proposed structure of the regulatory subcomplex of eukaryotic IF2B.

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In vitro phosphorylation of initiation factor 2 alpha (aIF2 alpha) from hyperthermophilic archaeon Pyrococcus horikoshii OT3.

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28 October 2018

Functional molecular mapping of archaeal translation initiation factor 2.

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28 October 2018

eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.

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28 October 2018

Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation

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Purification of the eukaryotic initiation factor 2-eukaryotic initiation factor 2B complex and characterization of its guanine nucleotide exchange activity during protein synthesis initiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19616556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19616556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of protein synthesis in eukaryotes. Mode of action of eRF, an eIF-2-recycling factor from rabbit reticulocytes involved in GDP/GTP exchange

1 reference

https://pubmed.ncbi.nlm.nih.gov/19616556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 60 S ribosomal subunit as a carrier of eukaryotic initiation factor 2 and the site of reversing factor activity during protein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19616556

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.JMB.2009.07.030

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2 February 2020

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2 February 2020

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