How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis (Q34120299)

31 July 2017

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title

How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis (English)

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31 July 2017

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Michael B Yaffe

1

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PubMed ID

11911880

31 July 2017

language of work or name

English

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publication date

1 February 2002

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31 July 2017

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31 July 2017

513

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31 July 2017

1

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31 July 2017

53-57

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Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Protein kinase C inhibitor proteins. Purification from sheep brain and sequence similarity to lipocortins and 14-3-3 protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Interaction of the protein kinase Raf-1 with 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Activation of Raf-1 by 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Association of polyomavirus middle tumor antigen with 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Identification of a novel interaction of 14-3-3 with p190RhoGEF.

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

14-3-3 proteins: key regulators of cell division, signalling and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

14-3-3 proteins; bringing new definitions to scaffolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

14-3-3 proteins: structure, function, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Regulatory 14-3-3 protein-protein interactions in plant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Molecular evolution of the 14-3-3 protein family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Data mining the Arabidopsis genome reveals fifteen 14-3-3 genes. Expression is demonstrated for two out of five novel genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

The structural basis for 14-3-3:phosphopeptide binding specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Differences in spatial expression between 14-3-3 isoforms in germinating barley embryos

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Molecular cloning of rat cDNAs for beta and gamma subtypes of 14-3-3 protein and developmental changes in expression of their mRNAs in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Developmental regulation of neuronal expression for the eta subtype of the 14-3-3 protein, a putative regulatory protein for protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Cloning and characterization of the epsilon and zeta isoforms of the 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

The mouse 14-3-3 epsilon isoform, a kinase regulator whose expression pattern is modulated in mesenchyme and neuronal differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Developmental regulation of 14-3-3 epsilon isoform in rat heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Olfactory learning deficits in mutants for leonardo, a Drosophila gene encoding a 14-3-3 protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Identification of genes overexpressed in head and neck squamous cell carcinoma using a combination of complementary DNA subtraction and microarray analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Increased expression of epidermal fatty acid binding protein, cofilin, and 14-3-3-sigma (stratifin) detected by two-dimensional gel electrophoresis, mass spectrometry and microsequencing of drug-resistant human adenocarcinoma of the pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Enhanced expression of 14-3-3 family members in injured motoneurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Demonstration of the phosphorylation-dependent interaction of tryptophan hydroxylase with the 14-3-3 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Identification of a binding sequence for the 14-3-3 protein within the cytoplasmic domain of the adhesion receptor, platelet glycoprotein Ib alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Binding of 14-3-3 protein to the plasma membrane H(+)-ATPase AHA2 involves the three C-terminal residues Tyr(946)-Thr-Val and requires phosphorylation of Thr(947).

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Crystal structure of the zeta isoform of the 14-3-3 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

14-3-3 proteins: regulation of subcellular localization by molecular interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Disruption of the 14-3-3 binding site within the B-Raf kinase domain uncouples catalytic activity from PC12 cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

A novel rap1/B-Raf/14-3-3 theta protein complex is formed in vivo during the morphogenetic differentiation of postmeiotic male germ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Brain 14-3-3 protein is an activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+,calmodulin-dependent protein kinase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Evolution of the 14-3-3 protein family: does the large number of isoforms in multicellular organisms reflect functional specificity?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Conditional rescue of olfactory learning and memory defects in mutants of the 14-3-3zeta gene leonardo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

BRCA1 is a selective co-activator of 14-3-3 sigma gene transcription in mouse embryonic stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Interaction of 14-3-3 with a nonphosphorylated protein ligand, exoenzyme S of Pseudomonas aeruginosa

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Glucocorticoid receptor interaction with 14-3-3 and Raf-1, a proposed mechanism for cross-talk of two signal transduction pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

Bcr and Raf form a complex in vivo via 14-3-3 proteins.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2903288-4

10.1016/S0014-5793(01)03288-4

7 January 2021

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11911880