Drug design at peptide receptors: somatostatin receptor ligands (Q34121891)

31 July 2017

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title

Drug design at peptide receptors: somatostatin receptor ligands (English)

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31 July 2017

Daniel Hoyer

9

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author name string

Jason P Hannon

1

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31 July 2017

Caroline Nunn

2

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31 July 2017

Barbara Stolz

3

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31 July 2017

Christians Bruns

4

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31 July 2017

Gisbert Weckbecker

5

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31 July 2017

Ian Lewis

6

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31 July 2017

Thomas Troxler

7

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31 July 2017

Konstanze Hurth

8

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31 July 2017

1 February 2002

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Journal of Molecular Neuroscience

31 July 2017

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31 July 2017

18

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31 July 2017

15-27

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31 July 2017

1-2

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https://scigraph.springernature.com/pub.10.1385/jmn:18:1-2:15

31 July 2017

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cites work

Two types of somatostatin receptors differentiated by cyclic somatostatin analogs.

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12 December 2020

Analogues of somatostatin bind selectively to brain somatostatin receptor subtypes

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12 December 2020

Development of a selective agonist at the somatostatin receptor subtype sstr1

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12 December 2020

Optimization of a somatostatin mimetic via constrained amino acid and backbone incorporation

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12 December 2020

Activation of somatostatin receptor subtype 2 inhibits acid secretion in rats

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12 December 2020

Processing of rat preprocortistatin in mouse AtT-20 cells

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12 December 2020

The somatostatin receptor-targeted radiotherapeutic [90Y-DOTA-DPhe1, Tyr3]octreotide (90Y-SMT 487) eradicates experimental rat pancreatic CA 20948 tumours.

1 reference

12 December 2020

N-terminally extended somatostatin: the primary structure of somatostatin-28

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12 December 2020

Somatostatin receptors

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12 December 2020

Characterization of cloned somatostatin receptors SSTR4 and SSTR5.

1 reference

12 December 2020

Expression cloning of a rat brain somatostatin receptor cDNA

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12 December 2020

1 reference

12 December 2020

Characterisation of human recombinant somatostatin receptors. 4. Modulation of phospholipase C activity.

1 reference

12 December 2020

Receptor isoforms mediate opposing proliferative effects through gbetagamma-activated p38 or Akt pathways

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12 December 2020

Highly potent cyclic disulfide antagonists of somatostatin.

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12 December 2020

Characterisation of human recombinant somatostatin receptors. 3. Modulation of adenylate cyclase activity

1 reference

12 December 2020

Characterisation of human recombinant somatostatin receptors. 2. Modulation of GTPgammaS binding

1 reference

12 December 2020

Identification and characterisation of heterogeneous somatostatin binding sites in rat distal colonic mucosa

1 reference

12 December 2020

Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2

1 reference

12 December 2020

SMS 201–995: A very potent and selective octapeptide analogue of somatostatin with prolonged action

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12 December 2020

Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides

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12 December 2020

Characterization of somatostatin receptors in guinea-pig isolated ileum, vas deferens and right atrium

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12 December 2020

Potentiation of the anti-proliferative effects of anti-cancer drugs by octreotide in vitro and in vivo

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12 December 2020

A linear hexapeptide somatostatin antagonist blocks somatostatin activity in vitro and influences growth hormone release in rats

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12 December 2020

Induction of wild-type p53, Bax, and acidic endonuclease during somatostatin-signaled apoptosis in MCF-7 human breast cancer cells

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12 December 2020

Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype

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12 December 2020

Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20

1 reference

12 December 2020

The neurobiology of somatostatin

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12 December 2020

Peptide folding induces high and selective affinity of a linear and small beta-peptide to the human somatostatin receptor 4.

1 reference

12 December 2020

Cloning of a cDNA Encoding a Novel Putative G-Protein–Coupled Receptor Expressed in Specific Rat Brain Regions

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12 December 2020

Lipophilization of somatostatin analog RC-160 with long chain fatty acid improves its anti-proliferative activity on human oral carcinoma cells in vitro

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12 December 2020

Cloning, expression, pharmacology and tissue distribution of the mouse somatostatin receptor subtype 5.

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12 December 2020

Cloning and characterization of a fourth human somatostatin receptor

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12 December 2020

Somatostatin receptors

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12 December 2020

Binding properties of somatostatin receptor subtypes

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12 December 2020

Evidence that somatostatin is localized and synthesized in lymphoid organs

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12 December 2020

Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry

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12 December 2020

Characterization of somatostatin receptor subtypes controlling rat gastric acid and pancreatic amylase release

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12 December 2020

Cloning of the mouse SSTR5 gene

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12 December 2020

Somatostatin receptors in Neuro2A neuroblastoma cells: ligand internalization

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12 December 2020

A selective analog for the somatostatin sst1-receptor subtype expressed by human tumors

1 reference

12 December 2020

Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase

1 reference

12 December 2020

Molecular pharmacology of somatostatin receptors

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12 December 2020

Activation of adenylate cyclase by human recombinant sst5 receptors expressed in CHO-K1 cells and involvement of Galphas proteins

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12 December 2020

Identification and characterization of subtype selective somatostatin receptor agonists

1 reference

12 December 2020

Cloning and expression of a novel mouse somatostatin receptor (SSTR2B).

1 reference

12 December 2020

Somatostatin (second of two parts).

1 reference

12 December 2020

sst2 somatostatin receptor expression reverses tumorigenicity of human pancreatic cancer cells.

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12 December 2020

Selective effects of somatostatin-14, -25 and -28 on in vitro insulin and glucagon secretion

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12 December 2020

[125I]Tyr10-cortistatin14 labels all five somatostatin receptors

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12 December 2020

Processing and intracellular targeting of prosomatostatin-derived peptides: the role of mammalian endoproteases.

1 reference

12 December 2020

Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of a somatostatin-14 receptor in rat brain

1 reference

12 December 2020

Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice

1 reference

12 December 2020

SST3-selective potent peptidic somatostatin receptor antagonists

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12 December 2020

Somatostatin in the central nervous system: physiology and pathological modifications

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12 December 2020

The Role of Somatostatin and Its Analogs in the Diagnosis and Treatment of Tumors

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12 December 2020

The somatostatin receptor subtype on rat enterochromaffinlike cells

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12 December 2020

Somatostatin receptor subtype 2 mediates somatostatin inhibition of ion secretion in rat distal colon.

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12 December 2020

Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers

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12 December 2020

Synthesis of a substance P antagonist with a somatostatin scaffold: factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry

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12 December 2020

Effects of somatostatin on the secretion of thyrotropin and prolactin

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12 December 2020

Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation.

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12 December 2020

Specific inhibition of rat pancreatic insulin or glucagon release by receptor-selective somatostatin analogs

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12 December 2020

Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4

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12 December 2020

Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5).

1 reference

12 December 2020

Identification and characterization of novel somatostatin antagonists

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12 December 2020

Differential distribution of somatostatin receptor subtypes in rat brain revealed by newly developed somatostatin analogs

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12 December 2020

The role of radioactive somatostatin and its analogues in the control of tumor growth

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12 December 2020

Molecular cloning and functional expression of a brain-specific somatostatin receptor

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12 December 2020

Somatostatin receptor subtype 2 mediates inhibition of gastrin and histamine secretion from human, dog, and rat antrum

1 reference

12 December 2020

Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28

1 reference

12 December 2020

Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity

1 reference

12 December 2020

Somatostatin and its receptor family

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12 December 2020

Selective somatostatin sst(2) receptor blockade with the novel cyclic octapeptide, CYN-154806.

1 reference

12 December 2020

Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase

1 reference

12 December 2020

Somatostatin receptor subtype 3 mediates the inhibitory action of somatostatin on gastric smooth muscle cells

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12 December 2020

Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney

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12 December 2020

Inhibition of muscle cell relaxation by somatostatin: tissue-specific, cAMP-dependent, pertussis toxin-sensitive

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12 December 2020

Glycosylation affects agonist binding and signal transduction of the rat somatostatin receptor subtype 3

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12 December 2020

Isolation and characterization of the mouse (Mus musculus) somatostatin receptor type-4-encoding gene (mSSTR4).

1 reference

12 December 2020

Molecular biology of somatostatin receptors

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12 December 2020

Peptides derived from cleavage of prosomatostatin at carboxyl- and amino-terminal segments. Characterization of tissue and secreted forms in the rat.

1 reference

12 December 2020

Development of somatostatin receptor subtype selective agonists through combinatorial chemistry

1 reference

12 December 2020

Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies

1 reference

12 December 2020

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

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12 December 2020

A cortical neuropeptide with neuronal depressant and sleep-modulating properties

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12 December 2020

Characterization of human recombinant somatostatin sst5 receptors mediating activation of phosphoinositide metabolism

1 reference

12 December 2020

Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms

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12 December 2020

A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides

1 reference

12 December 2020

Identification and characterization of a novel human cortistatin-like peptide

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12 December 2020

Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation

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12 December 2020

The elucidation of somatostatin receptor functions: a current view

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12 December 2020

Evidence for two somatostatin-14 receptor types in rat brain cortex

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12 December 2020

Molecular pharmacology of somatostatin receptor subtypes

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12 December 2020

Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28

1 reference

12 December 2020

Involvement of the Sst1 somatostatin receptor subtype in the intrahypothalamic neuronal network regulating growth hormone secretion: an in vitro and in vivo antisense study

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12 December 2020

Identifiers

DOI

10.1385/JMN:18:1-2:15

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Dimensions Publication ID

31 July 2017

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