T-helper type 2 cell-directed therapy for asthma (Q34126172)

31 July 2017

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title

T-helper type 2 cell-directed therapy for asthma (English)

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31 July 2017

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Cohn L

1

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PubMed ID

11150597

31 July 2017

Ray A

series ordinal

2

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31 July 2017

1 November 2000

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Pharmacology & Therapeutics

31 July 2017

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31 July 2017

88

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31 July 2017

2

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31 July 2017

187-196

1 reference

Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses.

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Therapeutic strategies for allergic diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Activated T-lymphocytes and eosinophils in the bronchial mucosa in isocyanate-induced asthma.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Interleukin 4 is localized to and released by human mast cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Could asthma be worsened by stimulating the T-helper type 1 immune response?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Cyclic AMP activates p38 mitogen-activated protein kinase in Th2 cells: phosphorylation of GATA-3 and stimulation of Th2 cytokine gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Do allergens induce type-2 immune responses?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Regulation of IgE production by beta 2-adrenoceptor agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

T lymphocyte activation in acute severe asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Long-term clinical efficacy of grass-pollen immunotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Airway remodeling in asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guérin (BCG) suppresses allergen-induced airway eosinophilia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Regulation of IgE and cytokine production by cAMP: implications for extrinsic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Effect of eight weeks of treatment with salmeterol on bronchoalveolar lavage inflammatory indices in asthmatics

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Requirement for IL-13 independently of IL-4 in experimental asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Vaccination with heat-killed Listeria as adjuvant reverses established allergen-induced airway hyperreactivity and inflammation: role of CD8+ T cells and IL-18

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Recombinant interleukin 12 cures mice infected with Leishmania major

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

A potential vaccine strategy for asthma and allied atopic diseases during early childhood.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

The one-two of T helper cells: does interferon-gamma knock out the Th2 hypothesis for asthma?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Disodium cromoglycate inhibits activation of human inflammatory cells in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Distinct functional phenotypes of cloned Ia-restricted helper T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Mechanisms and therapeutic applications of immune stimulatory cpG DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Role of protein tyrosine kinases in CD40/interleukin-4-mediated isotype switching to IgE

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Cytokine mRNA profile and cell activation in bronchoalveolar lavage fluid from nonatopic patients with symptomatic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Aerosolized recombinant interferon-gamma prevents antigen-induced eosinophil recruitment in mouse trachea

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Gene expression of the GATA-3 transcription factor is increased in atopic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Late asthmatic responses

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

T cell response to Mycobacterium tuberculosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Antagonism of nuclear factor-kappa B functions by steroid hormone receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Measles and atopy in Guinea-Bissau

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

The inverse association between tuberculin responses and atopic disorder.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Activation of the Interleukin-5 Promoter by cAMP in Murine EL-4 Cells Requires the GATA-3 and CLE0 Elements

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Local expansion of allergen-specific CD30+Th2-type gamma delta T cells in bronchial asthma.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Transcription factor GATA-3 is required for development of the T-cell lineage

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Immunologic basis of antigen-induced airway hyperresponsiveness

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Interleukin-13: central mediator of allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Beta 2-adrenergic receptors on eosinophils. Binding and functional studies

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7

7 January 2021

10.1016/S0163-7258(00)00091-7

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11150597