Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. (Q34126257)

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English	Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.	scientific article

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9 January 2020

Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents (English)

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9 January 2020

phosphorylation

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inferred from title

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insulin resistance

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Katsutaro Morino

1

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9 January 2020

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9 January 2020

Gerald I. Shulman

12

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9 January 2020

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Sylvie Dufour

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9 January 2020

Susanne Neschen

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Susanne Neschen

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9 January 2020

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Douglas Befroy

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9 January 2020

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Saki Sono

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9 January 2020

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Marc Pypaert

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9 January 2020

Kitt Falk Petersen

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Kitt Falk Petersen

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9 January 2020

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Jared Frattini

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9 January 2020

Nadine Shatzkes

6

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9 January 2020

Morris F White

8

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9 January 2020

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10 November 2005

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9 January 2020

Journal of Clinical Investigation

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9 January 2020

115

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9 January 2020

3587-3593

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9 January 2020

12

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9 January 2020

Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins

1 reference

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Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

1 reference

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Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts

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AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

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Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

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Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

1 reference

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Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes

1 reference

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Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

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Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.

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1 reference

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1 reference

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A microfluorometric method for the determination of free fatty acids in plasma

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1 reference

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1 reference

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1 reference

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Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function

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https://pubmed.ncbi.nlm.nih.gov/16284649

12 December 2020

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10.1172/JCI25151

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Europe PubMed Central

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9 January 2020

1 reference

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9 January 2020

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