Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins (Q34127850)

31 July 2017

Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins (English)

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31 July 2017

Darius Ghaderi

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31 July 2017

Rachel E Taylor

2

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31 July 2017

Vered Padler-Karavani

3

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31 July 2017

Sandra Diaz

4

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31 July 2017

Ajit Varki

5

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31 July 2017

25 July 2010

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31 July 2017

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31 July 2017

28

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31 July 2017

863-867

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31 July 2017

8

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https://scigraph.springernature.com/pub.10.1038/nbt.1651

31 July 2017

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cites work

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Effects of culture conditions on N-glycolylneuraminic acid (Neu5Gc) content of a recombinant fusion protein produced in CHO cells

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Expression systems for therapeutic glycoprotein production.

5 July 2018

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Carbohydrate analysis throughout the development of a protein therapeutic

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Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium

5 July 2018

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How to systematically evaluate immunogenicity of therapeutic proteins - regulatory considerations

5 July 2018

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Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products

5 July 2018

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5 July 2018

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Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins

5 July 2018

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N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution

5 July 2018

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5 July 2018

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Human embryonic stem cells express an immunogenic nonhuman sialic acid

5 July 2018

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Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells

5 July 2018

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Immune response, accommodation, and tolerance to transplantation carbohydrate antigens

5 July 2018

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Nontypeable Haemophilus influenzae strain 2019 produces a biofilm containing N-acetylneuraminic acid that may mimic sialylated O-linked glycans

5 July 2018

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5 July 2018

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5 July 2018

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Biosynthesis of N-glycolyneuraminic acid. The primary site of hydroxylation of N-acetylneuraminic acid is the cytosolic sugar nucleotide pool

5 July 2018

1 reference

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Immunological property of antibodies against N-glycolylneuraminic acid epitopes in cytidine monophospho-N-acetylneuraminic acid hydroxylase-deficient mice

5 July 2018

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Mechanism for increased immunogenicity of vaccines that form in vivo immune complexes with the natural anti-Gal antibody.

28 October 2018

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28 October 2018

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Complement targeting of nonhuman sialic acid does not mediate cell death of human embryonic stem cells.

28 October 2018

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The influence of natural antibody specificity on antigen immunogenicity

28 October 2018

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Pharmacokinetic profile of cetuximab (Erbitux) alone and in combination with irinotecan in patients with advanced EGFR-positive adenocarcinoma

28 October 2018

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Proteomic comparison of human and great ape blood plasma reveals conserved glycosylation and differences in thyroid hormone metabolism

28 October 2018

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28 October 2018

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Failure of human immunoresponse to N-glycolylneuraminic acid epitope contained in recombinant human erythropoietin

28 October 2018

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12 December 2020

Medicine. A history lesson for stem cells

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12 December 2020

Evaluation of seven commercial ELISA kits compared with the C1q solid-phase binding RIA for detection of circulating immune complexes

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12 December 2020

Sialylated carbohydrate chains of recombinant human glycoproteins expressed in Chinese hamster ovary cells contain traces of N -glycolylneuraminic acid

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12 December 2020

Identifiers

DOI

10.1038/NBT.1651

1 reference

Dimensions Publication ID

31 July 2017

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1 reference

31 July 2017

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