Sphingosine 1-phosphate, a key cell signaling molecule (Q34128454)

31 July 2017

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title

Sphingosine 1-phosphate, a key cell signaling molecule (English)

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31 July 2017

1

Sarah Spiegel

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31 July 2017

Sheldon Milstien

2

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PubMed ID

12011102

31 July 2017

language of work or name

English

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publication date

13 May 2002

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Journal of Biological Chemistry

31 July 2017

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31 July 2017

277

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31 July 2017

25851-25854

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31 July 2017

29

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Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

31 July 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Functions of a new family of sphingosine-1-phosphate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Sphingosine 1-phosphate signalling in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Lysophospholipids--receptor revelations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

G proteins and small GTPases: distant relatives keep in touch.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Pericyte loss and microaneurysm formation in PDGF-B-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Characterization of a novel sphingosine 1-phosphate receptor, Edg-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Cyclooxygenases: structural, cellular, and molecular biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Sphingosine-1-phosphate: signaling inside and out.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Tumor necrosis factor- induces adhesion molecule expression through the sphingosine kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Drought-induced guard cell signal transduction involves sphingosine-1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Molecular cloning and functional characterization of murine sphingosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Bimodal regulation of ceramidase by interleukin-1beta. Implications for the regulation of cytochrome p450 2C11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

An oncogenic role of sphingosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Mammalian lipid phosphate phosphohydrolases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

Sphingolipid transport: rafts and translocators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R200007200

21 January 2018

Identifiers

DOI

10.1074/JBC.R200007200

1 reference

31 July 2017

1 reference

PubMed ID

12011102