Role of water in the catalytic cycle of E. coli dihydrofolate reductase (Q34129428)

31 July 2017

title

Role of water in the catalytic cycle of E. coli dihydrofolate reductase (English)

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31 July 2017

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Paul Shrimpton

1

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31 July 2017

Rudolf K Allemann

series ordinal

2

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31 July 2017

publication date

1 June 2002

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31 July 2017

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31 July 2017

volume

11

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31 July 2017

issue

6

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31 July 2017

page(s)

1442-1451

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Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate

31 July 2017

cites work

1 reference

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NMR Studies of Ligand Binding to Dihydrofolate Reductase

28 July 2018

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Stretching exercises--flexibility in dihydrofolate reductase catalysis

28 July 2018

1 reference

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Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

28 July 2018

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Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4

28 July 2018

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Determination by Raman spectroscopy of the pKa of N5 of dihydrofolate bound to dihydrofolate reductase: mechanistic implications

28 July 2018

1 reference

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Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications

28 July 2018

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Detection of long-lived bound water molecules in complexes of human dihydrofolate reductase with methotrexate and NADPH.

28 July 2018

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Functional role of aspartic acid-27 in dihydrofolate reductase revealed by mutagenesis

28 July 2018

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Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

28 July 2018

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Mechanism of the reaction catalyzed by dihydrofolate reductase from Escherichia coli: pH and deuterium isotope effects with NADPH as the variable substrate

28 July 2018

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28 July 2018

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Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding

28 July 2018

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Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis

28 July 2018

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Theoretical studies on the dihydrofolate reductase mechanism: electronic polarization of bound substrates

28 July 2018

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The function of amino acid residues contacting the nicotinamide ring of NADPH in dihydrofolate reductase from Escherichia coli

28 July 2018

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Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin

28 July 2018

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Hydrogen bonding in globular proteins

28 July 2018

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A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

21 January 2018

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Triosephosphate isomerase: a theoretical comparison of alternative pathways

21 January 2018

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Energetically most likely substrate and active-site protonation sites and pathways in the catalytic mechanism of dihydrofolate reductase

21 January 2018

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Dynamics of a flexible loop in dihydrofolate reductase from Escherichia coli and its implication for catalysis.

21 January 2018

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Comparison of simple potential functions for simulating liquid water

21 January 2018

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Dissociation constants for dihydrofolic acid and dihydrobiopterin and implications for mechanistic models for dihydrofolate reductase

21 January 2018

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Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

21 January 2018

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13C and 15N nuclear magnetic resonance evidence of the ionization state of substrates bound to bovine dihydrofolate reductase

21 January 2018

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Domain motions in dihydrofolate reductase: a molecular dynamics study

21 January 2018

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Directed mutagenesis of dihydrofolate reductase

21 January 2018

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Direct Measurement of the pKaof Aspartic Acid 26 inLactobacillus caseiDihydrofolate Reductase: Implications for the Catalytic Mechanism

21 January 2018

1 reference

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Molecular dynamics simulations of the docking of substituted N5-deazapterins to dihydrofolate reductase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12021443

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Functional role of a mobile loop of Escherichia coli dihydrofolate reductase in transition-state stabilization

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12021443

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1110/PS.5060102

1 reference

31 July 2017

1 reference

31 July 2017

1 reference