Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. (Q34130536)

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English	Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways.	scientific article

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9 February 2020

Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways (English)

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9 February 2020

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9 February 2020

David Piwnica-Worms

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David Piwnica-Worms

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9 February 2020

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Ping Zhou

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9 February 2020

Shimon Gross

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9 February 2020

Ji-Hua Liu

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9 February 2020

Bo-Yang Yu

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9 February 2020

Ling-Ling Feng

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9 February 2020

Vijay Sharma

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9 February 2020

Samuel X Qiu

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9 February 2020

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9 August 2010

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9 February 2020

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9 February 2020

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9 February 2020

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9 February 2020

4722-4732

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9 February 2020

Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats

1 reference

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28 July 2018

Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes.

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28 July 2018

Molecular imaging strategies for drug discovery and development

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28 July 2018

Mitochondrial glutathione transport: physiological, pathological and toxicological implications.

1 reference

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28 July 2018

The anti-death machinery in IKK/NF-kappaB signaling

1 reference

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28 July 2018

Stimulus specificity of gene expression programs determined by temporal control of IKK activity

1 reference

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28 July 2018

Hepatic mitochondrial glutathione: transport and role in disease and toxicity.

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28 July 2018

Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury

1 reference

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28 July 2018

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

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28 July 2018

Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury.

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28 July 2018

Signaling to NF-kappaB

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28 July 2018

Molecular mechanisms of echinocystic acid-induced apoptosis in HepG2 cells

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28 July 2018

Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells

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28 July 2018

JNK activation is critical for Aplidin-induced apoptosis.

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28 July 2018

In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones

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28 July 2018

Analysis of glutathione: implication in redox and detoxification

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28 July 2018

Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity

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28 July 2018

Therapeutic potential of kava in the treatment of anxiety disorders

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28 July 2018

Anxiolytic-like effects of kava-kava in the elevated plus maze test--a comparison with diazepam.

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28 July 2018

Kava-kava and anxiety: growing knowledge about the efficacy and safety

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28 July 2018

Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses

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28 July 2018

An IkappaBalpha inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-kappaB-independent mechanism

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28 July 2018

Nuclear factor kappaB-dependent mechanisms coordinate the synergistic effect of PMA and cytokines on the induction of superoxide dismutase 2

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28 July 2018

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice

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28 July 2018

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

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28 July 2018

Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality

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28 July 2018

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

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28 July 2018

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

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28 July 2018

Kava: an overview

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28 July 2018

Inhibition of TNFalpha-induced activation of nuclear factor kappaB by kava (Piper methysticum) derivatives

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28 October 2018

The IKK NF-kappa B system: a treasure trove for drug development

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28 October 2018

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28 October 2018

Aqueous kava extracts do not affect liver function tests in rats

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Imaging 26S proteasome activity and inhibition in living mice

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28 October 2018

Identification of novel electrophilic metabolites of piper methysticum Forst (Kava).

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28 October 2018

Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes

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28 October 2018

Piperidine alkaloids from Piper methysticum

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28 October 2018

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28 October 2018

Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice

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28 October 2018

Inhibition of human cytochrome P450 activities by kava extract and kavalactones

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28 October 2018

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28 October 2018

Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes

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9 December 2018

From the Centers for Disease Control and Prevention. Hepatic toxicity possibly associated with kava-containing products--United States, Germany, and Switzerland, 1999-2002

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12 December 2020

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Kava hepatotoxicity with Western herbal products: does it occur with traditional kava use?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20696856

12 December 2020

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Fatal fulminant hepatic failure induced by a natural therapy containing kava

1 reference

https://pubmed.ncbi.nlm.nih.gov/20696856

12 December 2020

based on heuristic

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Kava hepatotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20696856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20696856

12 December 2020

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inferred from PubMed ID database lookup

Real-time imaging of ligand-induced IKK activation in intact cells and in living mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20696856

12 December 2020

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Monitoring proteasome activity in cellulo and in living animals by bioluminescent imaging: technical considerations for design and use of genetically encoded reporters

1 reference

https://pubmed.ncbi.nlm.nih.gov/20696856

12 December 2020

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SHIP1 Negatively Regulates Proliferation of Osteoclast Precursors via Akt-Dependent Alterations in D-Type Cyclins and p27

1 reference

https://pubmed.ncbi.nlm.nih.gov/20696856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic toxicity possibly associated with kava-containing products--United States, Germany, and Switzerland, 1999-2002

1 reference

https://pubmed.ncbi.nlm.nih.gov/20696856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute Hepatitis Induced by Kava Kava

1 reference

https://pubmed.ncbi.nlm.nih.gov/20696856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatitis induced by Kava (Piper methysticum rhizoma)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20696856

12 December 2020

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inferred from PubMed ID database lookup

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

1 reference

https://pubmed.ncbi.nlm.nih.gov/20696856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1096/FJ.10-163311

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9 February 2020

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9 February 2020

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9 February 2020

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