Dual inhibition of both the epidermal growth factor receptor and erbB2 effectively inhibits the promotion of skin tumors during two-stage carcinogenesis. (Q34130669)

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English	Dual inhibition of both the epidermal growth factor receptor and erbB2 effectively inhibits the promotion of skin tumors during two-stage carcinogenesis.	scientific article

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9 February 2020

Dual inhibition of both the epidermal growth factor receptor and erbB2 effectively inhibits the promotion of skin tumors during two-stage carcinogenesis (English)

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9 February 2020

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Hsiang-Chun Chang

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9 February 2020

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Kaoru Kiguchi

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9 February 2020

Takuya Kitamura

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9 February 2020

Tricia Moore

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9 February 2020

Mohammad Rumi

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9 February 2020

Devon Treece

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9 February 2020

Lynnsie Ruffino

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9 February 2020

Kevin Connolly

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9 February 2020

John DiGiovanni

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9 February 2020

publication date

3 August 2010

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9 February 2020

Cancer Prevention Research

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9 February 2020

3

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9 February 2020

8

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9 February 2020

940-952

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9 February 2020

Erbb2 suppresses DNA damage-induced checkpoint activation and UV-induced mouse skin tumorigenesis

1 reference

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5 July 2018

EGFR activation and ultraviolet light-induced skin carcinogenesis

1 reference

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5 July 2018

Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin

1 reference

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5 July 2018

Multiple mechanisms of Erbb2 action after ultraviolet irradiation of the skin

1 reference

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5 July 2018

Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation

1 reference

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Comparative analysis of the expression of ERBIN and Erb-B2 in normal human skin and cutaneous carcinomas

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Proliferation-differentiation relationships in the expression of heparin-binding epidermal growth factor-related factors and erbB receptors by normal and psoriatic human keratinocytes

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5 July 2018

The deaf and the dumb: the biology of ErbB-2 and ErbB-3

1 reference

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5 July 2018

The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor

1 reference

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5 July 2018

The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer

1 reference

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5 July 2018

Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes

1 reference

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5 July 2018

Ultraviolet irradiation activates PI 3-kinase/AKT survival pathway via EGF receptors in human skin in vivo.

1 reference

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5 July 2018

Coexpression patterns of EGFR, HER2, HER3 and HER4 in non-melanoma skin cancer.

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5 July 2018

Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development

1 reference

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5 July 2018

Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFalpha expression in transgenic mice

1 reference

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5 July 2018

Altered expression of epidermal growth factor receptor ligands in tumor promoter-treated mouse epidermis and in primary mouse skin tumors induced by an initiation-promotion protocol.

1 reference

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5 July 2018

Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers

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5 July 2018

Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles.

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5 July 2018

Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo

1 reference

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5 July 2018

The expression of c-erbB-1 and c-erbB-2 oncogenes in basal cell carcinoma and squamous cell carcinoma of skin

1 reference

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5 July 2018

Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-ras(Ha) oncogene but does not block in vitro keratinocyte responses to oncogenic ras.

1 reference

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5 July 2018

Increased level of c-erbB-2/neu/HER-2 protein in cutaneous squamous cell carcinoma

1 reference

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5 July 2018

Activation of erbB2 and c-src in phorbol ester-treated mouse epidermis: possible role in mouse skin tumor promotion

1 reference

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5 July 2018

Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice.

1 reference

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5 July 2018

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

1 reference

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5 July 2018

Structural analysis of p185c-neu and epidermal growth factor receptor tyrosine kinases: oligomerization of kinase domains

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5 July 2018

Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions

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5 July 2018

Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities

1 reference

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5 July 2018

ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer

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5 July 2018

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family

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5 July 2018

Transgenic mice provide genetic evidence that transforming growth factor alpha promotes skin tumorigenesis via H-ras-dependent and H-ras-independent pathways.

1 reference

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5 July 2018

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin

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5 July 2018

Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation

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5 July 2018

Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages

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Comparison of the histological changes in the skin of DBA/2 and C57BL/6 mice following exposure to various promoting agents

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5 July 2018

High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines.

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5 July 2018

Epidermal growth factor receptors in different skin tumors.

1 reference

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5 July 2018

Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3

1 reference

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5 July 2018

Distribution of neu (c-erbB-2) protein in human skin

1 reference

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5 July 2018

Measurement of chemically induced cell proliferation in rodent liver and kidney: a comparison of 5-bromo-2'-deoxyuridine and [3H]thymidine administered by injection or osmotic pump

1 reference

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5 July 2018

Signal transduction by receptors with tyrosine kinase activity

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5 July 2018

Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers

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5 July 2018

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation

1 reference

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5 July 2018

Growth factors and cancer

1 reference

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5 July 2018

Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis

1 reference

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5 July 2018

Growth factor signaling by receptor tyrosine kinases

1 reference

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5 July 2018

Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940063

28 October 2018

Differential gene expression in epidermis of mice sensitive and resistant to phorbol ester skin tumor promotion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940063

28 October 2018

Chemoprevention of UV light-induced skin tumorigenesis by inhibition of the epidermal growth factor receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940063

28 October 2018

A single physiologic dose of ultraviolet light exposure to human skin in vivo induces phosphorylation of epidermal growth factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940063

28 October 2018

The epidermal growth factor receptor is required to maintain the proliferative population in the basal compartment of epidermal tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940063

28 October 2018

Severe follicular hyperplasia and spontaneous papilloma formation in transgenic mice expressing the neu oncogene under the control of the bovine keratin 5 promoter

1 reference

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28 October 2018

Activation of the epidermal growth factor receptor by skin tumor promoters and in skin tumors from SENCAR mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940063

28 October 2018

Expression of EGF receptor, involucrin, and cytokeratins in basal cell carcinomas and squamous cell carcinomas of the skin

1 reference

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28 October 2018

Altered expression of the epidermal growth factor receptor and transforming growth factor-alpha during multistage skin carcinogenesis in SENCAR mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20682802

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted overexpression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/20682802

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal expression of transforming growth factor-alpha in transgenic mice: induction of spontaneous and 12-O-tetradecanoylphorbol-13-acetate-induced papillomas via a mechanism independent of Ha-ras activation or overexpression

1 reference

https://pubmed.ncbi.nlm.nih.gov/20682802

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical detection of the epidermal growth factor receptor in paraffin-embedded human tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/20682802

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the ability of 12-O-tetradecanoylphorbol-13-acetate to induce epidermal hyperplasia, transforming growth factor-alpha, and skin tumor promotion in wa-1 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20682802

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1940-6207.CAPR-10-0010

1 reference

Europe PubMed Central

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9 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20682802%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20682802%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

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