Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening (Q34130812)

31 July 2017

title

Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening (English)

1 reference

31 July 2017

10

Christopher P Austin

1 reference

31 July 2017

author name string

Matias S Attene-Ramos

1

1 reference

31 July 2017

Ruili Huang

2

1 reference

31 July 2017

Srilatha Sakamuru

3

1 reference

31 July 2017

Kristine L Witt

4

1 reference

31 July 2017

Gyda C Beeson

5

1 reference

31 July 2017

Louie Shou

6

1 reference

31 July 2017

Rick G Schnellmann

7

1 reference

31 July 2017

Craig C Beeson

8

1 reference

31 July 2017

Raymond R Tice

9

1 reference

31 July 2017

Menghang Xia

11

1 reference

31 July 2017

publication date

15 August 2013

1 reference

Chemical Research in Toxicology

31 July 2017

published in

1 reference

31 July 2017

volume

26

1 reference

31 July 2017

issue

9

1 reference

31 July 2017

page(s)

1323-1332

1 reference

Application of a homogenous membrane potential assay to assess mitochondrial function

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Cytotoxic effects of 109 reference compounds on rat H4IIE and human HepG2 hepatocytes. III: Mechanistic assays on oxygen consumption with MitoXpress and NAD(P)H production with Alamar Blue™.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

PubChem's BioAssay Database

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Investigating mitochondrial dysfunction to increase drug safety in the pharmaceutical industry

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Toxicity testing in the 21st century: a vision and a strategy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

A high-throughput respirometric assay for mitochondrial biogenesis and toxicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Genistein induces receptor and mitochondrial pathways and increases apoptosis during BCL-2 knockdown in human malignant neuroblastoma SK-N-DZ cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Mitochondrial kinases in cell signaling: Facts and perspectives

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Identification of chemical compounds that induce HIF-1alpha activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Mitochondrial off targets of drug therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Compound cytotoxicity profiling using quantitative high-throughput screening

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

The significance of mitochondrial toxicity testing in drug development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Mitochondria, oxidative stress and cell death

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

T channels and steroid biosynthesis: in search of a link with mitochondria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Development of a high throughput screening assay for mitochondrial membrane potential in living cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Mitochondrial targets of drug toxicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

The essential role of mitochondria in the biogenesis of cellular iron-sulfur proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Transport of protons across membranes by weak acids

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

The Effect of Uncouplers of Oxidative Phosphorylation on Oxygen Uptake, Ubiquinone Redox Status and Energy-Rich Phosphate Levels of Isolated Atria*

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Protonic conductance across phospholipid bilayer membranes induced by uncoupling agents for oxidative phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Studies on the mode of action of the phenolic antibacterial agent fentichlor against Staphylococcus aureus and Escherichia coli. 3. The effect of fentichlor on the metabolic activities of Staphylococcus aureus and Escherichia coli

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Action of the fungicides captan and folpet on rat liver mitochondria.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

The action of digitonin on rat liver mitochondria. The effects on enzyme content

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Uncoupling effect of fungal hydroxyanthraquinones on mitochondrial oxidative phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Organization of citric acid cycle enzymes into a multienzyme cluster

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Transcription and replication of animal mitochondrial DNAs.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Isoflavones promote mitochondrial biogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Dinitrophenol-induced mitochondrial uncoupling in vivo triggers respiratory adaptation in HepG2 cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

The effect of rotenone on respiration and its point of attack.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

The cristal membrane of mitochondria is the principal site of oxidative phosphorylation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Mitochondrial effects of triarylmethane dyes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4154066

Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells

28 October 2018

1 reference

12 December 2020

Assessment of mitochondrial toxicity in HepG2 cells cultured in high-glucose- or galactose-containing media

1 reference

12 December 2020

The effect of the phenolic antibacterial agent fentichlor on energy coupling in Staphylococcus aureus

1 reference

12 December 2020

Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform

1 reference

12 December 2020

The respiratory chain and oxidative phosphorylation

1 reference

12 December 2020

Ca ion uptake by rat kidney mitochondria and its dependence on respiration and phosphorylation

1 reference

12 December 2020

Identifiers

DOI

10.1021/TX4001754

1 reference

31 July 2017

1 reference

31 July 2017

1 reference