Progress in monitoring, modeling and control of bioprocesses during the last 20 years (Q34133819)

31 July 2017

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title

Progress in monitoring, modeling and control of bioprocesses during the last 20 years (English)

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31 July 2017

Schügerl K

1

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31 July 2017

publication date

1 February 2001

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31 July 2017

published in

Journal of Biotechnology

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31 July 2017

volume

85

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31 July 2017

issue

2

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31 July 2017

page(s)

149-173

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Carrier membrane as a stationary phase for affinity chromatography and kinetic studies of membrane-bound enzymes

31 July 2017

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On-line monitoring of monoclonal antibody formation in high density perfusion culture using FIA.

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7 January 2021

Electrospray ionization for mass spectrometry of large biomolecules

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7 January 2021

Electrospray ionization-principles and practice

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7 January 2021

Utilization of glucose and amino acids in insect cell cultures: Quantifying the metabolic flows within the primary pathways and medium development

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7 January 2021

High performance capillary electrophoresis

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7 January 2021

In vivo nuclear magnetic resonance analysis of immobilization effects on glucose metabolism of yeast Saccharomyces cerevisiae

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7 January 2021

A flow injection analysis system for fermentation monitoring and control

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7 January 2021

On-line monitoring of monoclonal antibody production with regenerable flow-injection immuno systems

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7 January 2021

Mass measurement at high molecular weight--new tools for biotechnologists

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7 January 2021

Direct determination of the cephalosporin transforming activity of immobilized cells with use of an enzyme thermistor. 1. Verification of the mathematical model.

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7 January 2021

Artificial neural network based experimental design procedure for enhancing fermentation development

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7 January 2021

Bioprocess supervision: neural networks and knowledge based systems.

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7 January 2021

Analysis of metabolic fluxes in batch and continuous cultures of Bacillus subtilis

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7 January 2021

Rapid and quantitative analysis of recombinant protein expression using pyrolysis mass spectrometry and artificial neural networks: application to mammalian cytochrome b5 in Escherichia coli.

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7 January 2021

Rapid and quantitative analysis of metabolites in fermentor broths using pyrolysis mass spectrometry with supervised learning: application to the screening of Penicillium chrysogenum fermentations for the overproduction of penicillins

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7 January 2021

Gene probe assays on a fibre-optic evanescent wave biosensor

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7 January 2021

Genetic manipulation of acid and solvent formation in clostridium acetobutylicum ATCC 824

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Specific heat flow rate: an on-line monitor and potential control variable of specific metabolic rate in animal cell culture that combines microcalorimetry with dielectric spectroscopy

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An on-line sampling system for fermentation monitoring using membrane inlet mass spectrometry (MIMS): application to phenoxyacetic acid monitoring in penicillin fermentation

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7 January 2021

Application of mathematical tools for metabolic design of microbial ethanol production

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7 January 2021

Analysis of plasmid-DNA and cell protein of recombinant Escherichia coli using capillary gel electrophoresis

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7 January 2021

Influence of the Dissolved Oxygen Concentration on the Penicillin Biosynthetic Pathway in Steady-State Cultures of Penicillium chrysogenum

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7 January 2021

Measurement of yeast intracellular pH by image processing and the change it undergoes during growth phase

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7 January 2021

Metabolic engineering of bacteria for ethanol production

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7 January 2021

Three methods of capillary electrophoresis compared with high-resolution agarose gel electrophoresis for serum protein electrophoresis

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7 January 2021

Metabolic flux distributions in recombinant Saccharomyces cerevisiae during foreign protein production

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7 January 2021

Metabolic flux distributions in Penicillium chrysogenum during fed-batch cultivations

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7 January 2021

Isolation of plasma proteins from the clotting cascade by heparin affinity chromatography

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7 January 2021

High-performance capillary electrophoresis in the biological sciences

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7 January 2021

Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons

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7 January 2021

Correlation of fermentation yield with yeast extract composition as characterized by near-infrared spectroscopy

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7 January 2021

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7 January 2021

Fuzzy supervisory control of glutamic acid production.

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7 January 2021

Continuous measurement of microbial heat production in laboratory fermentors

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7 January 2021

On-line determination of intracellular beta-galactosidase activity in recombinant Escherichia coli using flow injection analysis (FIA)

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7 January 2021

Detection of botulinum toxin using an evanescent wave immunosensor

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7 January 2021

Calorimetric control of fed-batch cultures of Saccharomyces cerevisiae

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7 January 2021

Use of microcalorimetric monitoring in establishing continuous energy balances and in continuous determinations of substrate and product concentrations of batch-grown Saccharomyces cerevisiae.

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7 January 2021

Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing.

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7 January 2021

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7 January 2021

Affinity chromatography supports: a look at performance requirements

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7 January 2021

Current developments in optical biochemical sensors

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7 January 2021

FIA for on-line monitoring of important lactic acid fermentation variables

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7 January 2021

Metabolic control analysis of the penicillin biosynthetic pathway in a high-yielding strain of Penicillium chrysogenum

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Metabolic effects on recombinant interferon-gamma glycosylation in continuous culture of Chinese hamster ovary cells

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7 January 2021

Prerequisites for the on-line control of microbial processes by flow injection analysis

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7 January 2021

Real-time monitoring of protein secretion in mammalian cell fermentation: measurement of monoclonal antibodies using a computer-controlled HPLC system (BioCad/RPM).

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7 January 2021

On-line control of an immobilized hybridoma culture with multi-channel flow injection analysis

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7 January 2021

Automation of selective assays for on-line bioprocess monitoring by flow-injection analysis

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7 January 2021

Metabolic flux distribution in Corynebacterium melassecola ATCC 17965 for various carbon sources.

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7 January 2021

Liquid chromatography and electrospray mass spectrometric mapping of peptides from human plasma filtrate

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7 January 2021

Implementation of a thermal biosensor in a process environment: on-line monitoring of penicillin V in production-scale fermentations

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7 January 2021

On-line monitoring of ethanol, acetaldehyde and glycerol during industrial fermentations with Saccharomyces cerevisiae

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7 January 2021

Characterization and application of strong ion-exchange membrane adsorbers as stationary phases in high-performance liquid chromatography of proteins

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7 January 2021

Fast on-line flow injection analysis system for IgG monitoring in bioprocesses

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7 January 2021

Simultaneous measurement of glucose and glutamine in insect cell culture media by near infrared spectroscopy

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7 January 2021

Re-use of spent cell culture medium in pilot scale and rapid preparative purification with membrane chromatography

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7 January 2021

In vivo investigations of glucose transport in Saccharomyces cerevisiae

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7 January 2021

In vivo analysis of metabolic dynamics in Saccharomyces cerevisiae: II. Mathematical model.

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7 January 2021

Multiple mechanisms controlling carbon metabolism in bacteria

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7 January 2021

Quantitative in vivo nuclear magnetic resonance studies of hybridoma metabolism

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7 January 2021

Two FIA-based biosensor systems studied for bioprocess monitoring

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7 January 2021

Flow injection analysis (FIA) based on enzymes or antibodies--applications in the life sciences

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7 January 2021

13C tracer experiments and metabolite balancing for metabolic flux analysis: comparing two approaches

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7 January 2021

On-line metabolic pathway analysis based on metabolic signal flow diagram.

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7 January 2021

Experimental determination of group flux control coefficients in metabolic networks

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7 January 2021

Control of glycolytic flux in Zymomonas mobilis by glucose 6-phosphate dehydrogenase activity

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7 January 2021

Electrospray mass spectrometry characterization of post-translational modifications of barley alpha-amylase 1 produced in yeast

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7 January 2021

Automatic bioprocess control. 1. A general concept

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7 January 2021

On-line study of fungal morphology during submerged growth in a small flow-through cell

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7 January 2021

On-line monitoring with feedback control of bioreactors using a high ethanol tolerance yeast by membrane introduction mass spectrometry

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7 January 2021

Metabolic engineering--methodologies and future prospects

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7 January 2021

Metabolic engineering

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7 January 2021

Automated mass spectrometry imaging with a matrix-assisted laser desorption ionization time-of-flight instrument

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7 January 2021

In situ microscopy for on-line characterization of cell-populations in bioreactors, including cell-concentration measurements by depth from focus

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7 January 2021

Intracellular pH based controlled cultivation of yeast cells: I. Measurement methodology

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7 January 2021

Intracellular pH-based controlled cultivation of yeast cells: II. cultivation methodology

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7 January 2021

Application of scanning fluorometry for monitoring of a fermentation process

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7 January 2021

In vivo 13C-NMR studies of polymer synthesis in rhizobium meliloti M5N1 strain

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7 January 2021

In vivo analysis of metabolic dynamics in Saccharomyces cerevisiae : I. Experimental observations

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7 January 2021

Morphological characterization of filamentous microorganisms in submerged cultures by on-line digital image analysis and pattern recognition

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7 January 2021

Closed-loop control of fed-batch cultures of recombinant Escherichia coli using on-line HPLC.

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7 January 2021

A near-infrarod spectroscopy technique for the control of fermentation processes: An application to lactic acid fermentation

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7 January 2021

Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction

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7 January 2021

Characterization of Penicillium chrysogenum physiology in submerged cultures by color and monochrome image analysis.

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7 January 2021

Optical triple sensor for measuring pH, oxygen and carbon dioxide

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7 January 2021

Electrospray interface for liquid chromatographs and mass spectrometers

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7 January 2021

Bidirectional reaction steps in metabolic networks: I. Modeling and simulation of carbon isotope labeling experiments.

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7 January 2021

Bidirectional reaction steps in metabolic networks: II. Flux estimation and statistical analysis.

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7 January 2021

Immunoadsorption: strategies for antigen elution and production of reusable adsorbents

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7 January 2021

Morphological analysis of yeast cells using an automated image processing system

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1656%2800%2900361-8

7 January 2021

Column-switching high-performance liquid chromatography combined with ionspray tandem mass spectrometry for the simultaneous determination of the platelet inhibitor Ro 44-3888 and its pro-drug and precursor metabolite in plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1656%2800%2900361-8

7 January 2021

Influence of medium composition on the cephalosporin C production with a highly productive strain Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1656%2800%2900361-8

7 January 2021

Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1656%2800%2900361-8

7 January 2021

Intracellular flux analysis in hybridomas using mass balances and in vitro (13)C nmr.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1656%2800%2900361-8

7 January 2021

10.1016/S0168-1656(00)00361-8

Identifiers

DOI

1 reference

31 July 2017

1 reference