Pancreatic organogenesis--developmental mechanisms and implications for therapy (Q34136625)

31 July 2017

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title

Pancreatic organogenesis--developmental mechanisms and implications for therapy (English)

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31 July 2017

Helena Edlund

1

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publication date

1 July 2002

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31 July 2017

Nature Reviews Genetics

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31 July 2017

3

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31 July 2017

524-532

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31 July 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrg841

31 July 2017

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beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

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The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas

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Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development

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neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

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The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas

31 March 2020

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The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity

31 March 2020

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A transcription factor regulatory circuit in differentiated pancreatic cells

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Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice

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Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo

31 March 2020

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Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice

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Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

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The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas.

31 March 2020

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HNF-6 is expressed in endoderm derivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors.

31 March 2020

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Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3

31 March 2020

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Epitheliomesenchymal interaction in pancreatic morphogenesis

31 March 2020

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Epidermal growth factor increases undifferentiated pancreatic embryonic cells in vitro: a balance between proliferation and differentiation.

31 March 2020

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Fibroblast growth factors as multifunctional signaling factors

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Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas.

31 March 2020

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Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning

31 March 2020

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FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development

31 March 2020

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Attenuation of FGF signalling in mouse β-cells leads to diabetes

31 March 2020

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Expression of nerve growth factor and its high-affinity receptor Trk-A in the rat pancreas during embryonic and fetal life

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31 March 2020

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Factors controlling pancreatic cell differentiation and function.

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Notch signalling controls pancreatic cell differentiation

31 March 2020

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Islet cell precursors are neurones

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Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets.

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Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons.

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Insulin production in a neuroectodermal tumor that expresses islet factor-1, but not pancreatic-duodenal homeobox 1.

31 March 2020

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31 March 2020

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Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice

31 March 2020

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Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas

31 March 2020

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Transdifferentiation versus stem cell hypothesis for the regeneration of islet beta-cells in the pancreas

31 March 2020

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Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

31 March 2020

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Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity

31 March 2020

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Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG841

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PubMed ID

12094230

Dimensions Publication ID

31 July 2017

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PubMed ID

12094230