Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity (Q34146925)

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English	Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity	scientific article

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scholarly article

1 reference

Europe PubMed Central

31 July 2017

Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity (English)

1 reference

Europe PubMed Central

31 July 2017

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1 reference

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author name string

P Rosenkranz-Weiss

1

1 reference

Europe PubMed Central

31 July 2017

W C Sessa

2

1 reference

Europe PubMed Central

31 July 2017

S Milstien

3

1 reference

Europe PubMed Central

31 July 2017

S Kaufman

4

1 reference

Europe PubMed Central

31 July 2017

C A Watson

5

1 reference

Europe PubMed Central

31 July 2017

J S Pober

6

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Europe PubMed Central

31 July 2017

language of work or name

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publication date

1 May 1994

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Europe PubMed Central

31 July 2017

Journal of Clinical Investigation

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Europe PubMed Central

31 July 2017

93

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Europe PubMed Central

31 July 2017

2236-2243

1 reference

Europe PubMed Central

31 July 2017

5

1 reference

Europe PubMed Central

31 July 2017

Regulation of muscle transcription by the MyoD family. The heart of the matter

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5 July 2018

Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Hepatocytes and macrophages express an identical cytokine inducible nitric oxide synthase gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Cloning of inducible nitric oxide synthase in rat vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Tetrahydrobiopterin is required for cytokine-induced nitric oxide production in a murine macrophage cell line (RAW 264).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP

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5 July 2018

Platelet adhesion to human vascular endothelium is modulated by constitutive and cytokine induced nitric oxide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin

1 reference

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5 July 2018

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Functional heterogeneity of vascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Relationship between neopterin and granulocyte elastase plasma levels and the severity of multiple organ failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

1 reference

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5 July 2018

Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.

1 reference

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5 July 2018

Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin.

1 reference

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5 July 2018

Cloning and sequencing of cDNA encoding rat GTP cyclohydrolase I. The first enzyme of the tetrahydrobiopterin biosynthetic pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Nitrogen oxide levels in patients after trauma and during sepsis

1 reference

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5 July 2018

Tumor necrosis factor and granulocyte macrophage-colony stimulating factor stimulate human macrophages to restrict growth of virulent Mycobacterium avium and to kill avirulent M. avium: killing effector mechanism depends on the generation of reactiv

1 reference

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5 July 2018

Impact of tumour necrosis factor-alpha and interferon-gamma on tetrahydrobiopterin synthesis in murine fibroblasts and macrophages

1 reference

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5 July 2018

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

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5 July 2018

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1 reference

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5 July 2018

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Nitric oxide synthesis in endothelial cells: evidence for a pathway inducible by TNF-alpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious, and malignant diseases

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5 July 2018

Effects of interferon-gamma on nitric oxide synthase activity and endothelin-1 production by vascular endothelial cells

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5 July 2018

Nitric oxide as a secretory product of mammalian cells

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5 July 2018

Calmodulin is a subunit of nitric oxide synthase from macrophages

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Molecular cloning and characterization of human endothelial nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity

1 reference

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5 July 2018

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Cloning and characterization of inducible nitric oxide synthase from mouse macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=294374

5 July 2018

Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells

1 reference

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5 July 2018

Identification of inducible calmodulin-dependent nitric oxide synthase in the liver of rats

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5 July 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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5 July 2018

Culture of vascular endothelium

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5 July 2018

Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle

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28 October 2018

GTP cyclohydrolase I mRNA is induced by LPS in vascular smooth muscle: characterization, sequence and relationship to nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/7514193

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https://pubmed.ncbi.nlm.nih.gov/7514193

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Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/7514193

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Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin

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https://pubmed.ncbi.nlm.nih.gov/7514193

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based on heuristic

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Analysis of reduced forms of biopterin in biological tissues and fluids

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https://pubmed.ncbi.nlm.nih.gov/7514193

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Hyperphenylalaninemia due to dihydropteridine reductase deficiency: diagnosis by measurement of oxidized and reduced pterins in urine

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https://pubmed.ncbi.nlm.nih.gov/7514193

12 December 2020

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Guanosine triphosphate cyclohydrolase I assay in human and rat liver using high-performance liquid chromatography of neopterin phosphates and guanine nucleotides

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Human endothelial cells: use of heparin in cloning and long-term serial cultivation

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https://pubmed.ncbi.nlm.nih.gov/7514193

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based on heuristic

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Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/7514193

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based on heuristic

inferred from PubMed ID database lookup

Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7514193

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based on heuristic

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Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/7514193

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Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/7514193

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Identifiers

10.1172/JCI117221

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

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