Galpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras. (Q34148749)

31 July 2017

title

Galpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras. (English)

1 reference

31 July 2017

John M Schmitt

1

1 reference

31 July 2017

Philip J S Stork

series ordinal

2

1 reference

31 July 2017

language of work or name

English

0 references

publication date

6 September 2002

1 reference

Journal of Biological Chemistry

31 July 2017

published in

1 reference

31 July 2017

volume

277

1 reference

31 July 2017

issue

45

1 reference

31 July 2017

page(s)

43024-43032

1 reference

G proteins: transducers of receptor-generated signals

31 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Receptor-to-effector signaling through G proteins: roles for beta gamma dimers as well as alpha subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

G-protein-coupled receptors and signaling networks: emerging paradigms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Suppression of Ras-induced transformation of NIH 3T3 cells by activated G alpha s.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Inhibition by cAMP of Ras-Dependent Activation of Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Rapid Ca2+-mediated activation of Rap1 in human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Src family kinases are required for integrin but not PDGFR signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Mechanisms and consequences of activation of protein kinase B/Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Analysis of the Gs/mitogen-activated protein kinase pathway in mutant S49 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Cyclic AMP-dependent activation of the proenkephalin gene requires phosphorylation of CREB at serine-133 and a Src-related kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Norepinephrine induces vascular endothelial growth factor gene expression in brown adipocytes through a beta -adrenoreceptor/cAMP/protein kinase A pathway involving Src but independently of Erk1/2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Beta 3- and alpha1-adrenergic Erk1/2 activation is Src- but not Gi-mediated in Brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Calcium-independent activation of extracellularly regulated kinases 1 and 2 by angiotensin II in hepatic C9 cells: roles of protein kinase Cdelta, Src/proline-rich tyrosine kinase 2, and epidermal growth receptor trans-activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Beta(2)-adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for G(s)/G(i) switching.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Requirement for c-Src catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogenic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Requirement for Src family protein tyrosine kinases in G2 for fibroblast cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Regulation of c-SRC activity and function by the adapter protein CAS

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Roles of cell-cell adhesion-dependent tyrosine phosphorylation of Gab-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Cas mediates transcriptional activation of the serum response element by Src.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Focal adhesions require catalytic activity of Src family kinases to mediate integrin-matrix adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Activation of the Rap1 GTPase by the B cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Ras signalling and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

A novel role for phosphatidylinositol 3-kinase beta in signaling from G protein-coupled receptors to Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Dual regulation of Akt/protein kinase B by heterotrimeric G protein subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Activation of mitogen-activated protein kinase by the A(2A)-adenosine receptor via a rap1-dependent and via a p21(ras)-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

Specific association of tyrosine-phosphorylated c-Cbl with Fyn tyrosine kinase in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204006200

21 January 2018

Identifiers

DOI

10.1074/JBC.M204006200

1 reference

31 July 2017

1 reference