A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia (Q34149960)

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15 January 2020

title

A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia (English)

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15 January 2020

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4

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author name string

Lacramioara Ivanciu

1

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15 January 2020

Raffaella Toso

2

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15 January 2020

Paris Margaritis

3

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15 January 2020

Haein Kim

5

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15 January 2020

Alexander Schlachterman

6

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15 January 2020

Jian-Hua Liu

7

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Valerie Clerin

8

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15 January 2020

Debra D Pittman

9

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Rosalind Rose-Miranda

10

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15 January 2020

Kathleen M Shields

11

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David V Erbe

12

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15 January 2020

James F Tobin

13

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Valder R Arruda

14

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Rodney M Camire

15

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publication date

23 October 2011

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15 January 2020

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volume

29

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issue

11

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15 January 2020

page(s)

1028-1033

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Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo.

15 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157830

Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitro

5 July 2018

1 reference

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Health economics in haemophilia: a review from the clinician's perspective

5 July 2018

1 reference

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Differential response to bypassing agents complicates treatment in patients with haemophilia and inhibitors

5 July 2018

1 reference

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Analysis of the spatial and temporal characteristics of platelet-delivered factor VIII-based clots

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157830

Tissue factor-independent effects of recombinant factor VIIa on hemostasis.

5 July 2018

1 reference

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Back to the future: a recent history of haemophilia treatment

5 July 2018

1 reference

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The conformational switch from the factor X zymogen to protease state mediates exosite expression and prothrombinase assembly

5 July 2018

1 reference

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Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality

5 July 2018

1 reference

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Inhibitor development in haemophilia B: an orphan disease in need of attention

5 July 2018

1 reference

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Mechanism of action, development and clinical experience of recombinant FVIIa

5 July 2018

1 reference

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Factor V Leiden improves in vivo hemostasis in murine hemophilia models

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157830

5 July 2018

FEIBA: mode of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157830

Novel therapeutic approach for hemophilia using gene delivery of an engineered secreted activated Factor VII.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157830

Platelets and thrombin generation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157830

Role of thrombin signalling in platelets in haemostasis and thrombosis

5 July 2018

1 reference

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A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state

5 July 2018

1 reference

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Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157830

Platelet activity of high-dose factor VIIa is independent of tissue factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157830

A coagulation factor IX-deficient mouse model for human hemophilia B.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157830

Studies of Factors V and VIII:C in an animal model of disseminated intravascular coagulation

5 July 2018

1 reference

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A combination of factor Xa and phosphatidylcholine-phosphatidylserine vesicles bypasses factor VIII in vivo

5 July 2018

1 reference

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The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

5 July 2018

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Surface-dependent reactions of the vitamin K-dependent enzyme complexes

5 July 2018

1 reference

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The incidence of factor VIII and factor IX inhibitors in the hemophilia population of the UK and their effect on subsequent mortality, 1977-99.

5 July 2018

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How factor VIIa works in hemophilia

21 January 2018

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Factor VIII inhibitor-bypassing agents act by inducing thrombin generation and can be monitored by a thrombin generation assay

21 January 2018

1 reference

Improved hemostasis with superactive analogs of factor VIIa in a mouse model of hemophilia A.

21 January 2018

1 reference

Evaluation of the safety and pharmacokinetics of a fast-acting recombinant FVIIa analogue, NN1731, in healthy male subjects

21 January 2018

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Human factor IX corrects the bleeding diathesis of mice with hemophilia B.

21 January 2018

1 reference

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Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse

28 October 2018

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12 December 2020

The coagulant-active phospholipid content is a major determinant of in vivo thrombogenicity of prothrombin complex (Factor IX) concentrates in rabbits

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12 December 2020

Radioimmunoassay of factor V in human plasma and platelets

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12 December 2020

Inhibition of human activated Factor X by antithrombin III and alpha 1-proteinase inhibitor in human plasma

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12 December 2020

Characterization of recombinant murine factor VIIa and recombinant murine tissue factor: a human-murine species compatibility study

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12 December 2020

Development of a calibrated automated thrombography based thrombin generation test in mouse plasma

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12 December 2020

Identifiers

DOI

10.1038/NBT.1995

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22020385%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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15 January 2020

PubMed publication ID

22020385

1 reference