Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity (Q34156274)

31 July 2017

Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity (English)

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31 July 2017

Naoyuki Yabana

1

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31 July 2017

Masabumi Shibuya

series ordinal

2

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31 July 2017

language of work or name

English

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publication date

1 October 2002

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31 July 2017

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31 July 2017

21

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31 July 2017

50

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31 July 2017

7720-7729

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205927

31 July 2017

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cites work

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Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity

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Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

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Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1.

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Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding

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Autoinhibition mechanism of proto-Dbl.

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Regulatory and signaling properties of the Vav family

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Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.

21 January 2018

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Does Vav bind to F‐actin through a CH domain?

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The Dbl family of oncogenes

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Genomic analysis of metastasis reveals an essential role for RhoC

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Biological assays for Ras transformation

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

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Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.

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Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

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Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

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Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins.

21 January 2018

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Rho GTPases and the actin cytoskeleton

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Lck regulates Vav activation of members of the Rho family of GTPases

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Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

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Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

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Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression

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Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation

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Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

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Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential

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Asef, a link between the tumor suppressor APC and G-protein signaling

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Oncogene ect2 is related to regulators of small GTP-binding proteins

21 January 2018

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Vav family proteins couple to diverse cell surface receptors

21 January 2018

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Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins

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Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

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21 January 2018

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Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins

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21 January 2018

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APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl

21 January 2018

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Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation

21 January 2018

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APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis

21 January 2018

1 reference

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Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation

21 January 2018

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Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

21 January 2018

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Single calponin homology domains are not actin-binding domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205927

7 January 2021

The yeast tribrid system--genetic detection of trans-phosphorylated ITAM-SH2-interactions.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205927

7 January 2021

Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205927

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205927

1 reference

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205927

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Dimensions Publication ID

31 July 2017

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1 reference