The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility (Q34157005)

31 July 2017

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility (English)

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31 July 2017

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3

Hilal A Lashuel

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31 July 2017

Yichin Liu

1

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31 July 2017

Lara Fallon

series ordinal

2

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31 July 2017

Zhihua Liu

series ordinal

4

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31 July 2017

Peter T Lansbury

series ordinal

5

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31 July 2017

language of work or name

English

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publication date

1 October 2002

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31 July 2017

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31 July 2017

111

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31 July 2017

209-218

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31 July 2017

2

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Impairment of the ubiquitin-proteasome system by protein aggregation

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Degradation of alpha-synuclein by proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Persistent activation of cAMP-dependent protein kinase by regulated proteolysis suggests a neuron-specific function of the ubiquitin system in Aplysia.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Cytosolic O-glycosylation is abundant in nerve terminals

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Kinetic and mechanistic studies on the hydrolysis of ubiquitin C-terminal 7-amido-4-methylcoumarin by deubiquitinating enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Identification of genes that modify ataxin-1-induced neurodegeneration.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Bioenergetic characterization of gamma-aminobutyric acid transporter of synaptic vesicles.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

In vitro assembly and recognition of Lys-63 polyubiquitin chains

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Structural basis for the specificity of ubiquitin C-terminal hydrolases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Genetics of Parkinson's disease and biochemical studies of implicated gene products

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

The ubiquitin protein catabolic disorders.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

The ubiquitin pathway in Parkinson's disease.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

No genetic association of the Ubiquitin Carboxy-terminal Hydrolase-L1 gene S18Y polymorphism with familial Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

E2/E3-mediated assembly of lysine 29-linked polyubiquitin chains

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Failure of the ubiquitin-proteasome system in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Progressive degeneration of motor nerve terminals in GAD mutant mouse with hereditary sensory axonopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Neuropathology of gracile axonal dystrophy (GAD) mouse. An animal model of central distal axonopathy in primary sensory neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Mutation analysis and association studies of the ubiquitin carboxy-terminal hydrolase L1 gene in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Dying back type axonal degeneration of sensory nerve terminals in muscle spindles of the gracile axonal dystrophy (GAD) mutant mouse

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Mechanisms underlying ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Amyloid fibrillogenesis: themes and variations

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Molecular crowding accelerates fibrillization of alpha-synuclein: could an increase in the cytoplasmic protein concentration induce Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Boundary analysis in sedimentation transport experiments: a procedure for obtaining sedimentation coefficient distributions using the time derivative of the concentration profile

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

ACT and UCH-L1 polymorphisms in Parkinson's disease and age of onset.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

Themes and variations on ubiquitylation

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2901012-7

7 January 2021

10.1016/S0092-8674(02)01012-7

Identifiers

DOI

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31 July 2017

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