Varied Molecular Interactions at the Active Sites of Several DNA Polymerases: Nonpolar Nucleoside Isosteres as Probes (Q34157423)

31 July 2017

title

Varied Molecular Interactions at the Active Sites of Several DNA Polymerases: Nonpolar Nucleoside Isosteres as Probes (English)

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31 July 2017

main subject

molecular interaction

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2

Eric T Kool

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31 July 2017

Juan C Morales

1

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31 July 2017

language of work or name

English

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publication date

1 February 2000

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Journal of the American Chemical Society

31 July 2017

published in

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31 July 2017

volume

122

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31 July 2017

issue

6

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31 July 2017

page(s)

1001-1007

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Aromatic Nonpolar Nucleosides as Hydrophobic Isosteres of Pyrimidine and Purine Nucleosides

31 July 2017

cites work

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Solution Structure of a Nonpolar, Non-Hydrogen-Bonded Base Pair Surrogate in DNA.

5 July 2018

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Hydrophobic, Non-Hydrogen-Bonding Bases and Base Pairs in DNA.

5 July 2018

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Structure and Base Pairing Properties of a Replicable Nonpolar Isostere for Deoxyadenosine

5 July 2018

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Minor Groove Interactions between Polymerase and DNA: More Essential to Replication than Watson-Crick Hydrogen Bonds?

5 July 2018

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Difluorotoluene, a Nonpolar Isostere for Thymine, Codes Specifically and Efficiently for Adenine in DNA Replication

5 July 2018

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C-Nucleosides Derived from Simple Aromatic Hydrocarbons

5 July 2018

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Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli

5 July 2018

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Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.

5 July 2018

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

5 July 2018

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Inhibition of DNA polymerase reactions by pyrimidine nucleotide analogues lacking the 2-keto group.

5 July 2018

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Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

5 July 2018

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Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

5 July 2018

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A thymidine triphosphate shape analog lacking Watson-Crick pairing ability is replicated with high sequence selectivity

5 July 2018

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Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism

5 July 2018

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Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69

5 July 2018

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DNA polymerase beta: structure-fidelity relationship from Pre-steady-state kinetic analyses of all possible correct and incorrect base pairs for wild type and R283A mutant

5 July 2018

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Structure of Taq polymerase with DNA at the polymerase active site

5 July 2018

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Non-hydrogen bonding 'terminator' nucleosides increase the 3'-end homogeneity of enzymatic RNA and DNA synthesis

5 July 2018

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Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase

5 July 2018

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Biochemical basis of DNA replication fidelity

5 July 2018

1 reference

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Structure of DNA polymerase I Klenow fragment bound to duplex DNA

5 July 2018

1 reference

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Recognition by viral and cellular DNA polymerases of nucleosides bearing bases with nonstandard hydrogen bonding patterns

5 July 2018

1 reference

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Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

5 July 2018

1 reference

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Fidelity of DNA synthesis

5 July 2018

1 reference

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Kinetic mechanism of DNA polymerase I (Klenow).

5 July 2018

1 reference

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Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946118

Molecular recognition in the minor groove of the DNA helix. Studies on the synthesis of oligonucleotides and polynucleotides containing 3-deaza-2'-deoxyadenosine. Interaction of the oligonucleotides with the restriction endonuclease EcoRV.

5 July 2018

1 reference

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Identification of residues critical for the polymerase activity of the Klenow fragment of DNA polymerase I from Escherichia coli

5 July 2018

1 reference

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Fidelity mechanisms in DNA replication

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946118

An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946118

Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946118

Appendix. Gel kinetic analysis of polymerase fidelity in the presence of multiple enzyme DNA encounters

5 July 2018

1 reference

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Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta.

28 October 2018

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Enthalpy-entropy compensation in DNA melting thermodynamics

28 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946118

Structural insights into DNA polymerase beta fidelity: hold tight if you want it right

28 October 2018

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12 December 2020

Replication of non-hydrogen bonded bases by DNA polymerases: a mechanism for steric matching

1 reference

12 December 2020

Bi-stranded, multisite replication of a base pair between difluorotoluene and adenine: confirmation by 'inverse' sequencing

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12 December 2020

Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase

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12 December 2020

Spectroscopic and calorimetric characterizations of DNA duplexes containing 2-aminopurine

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12 December 2020

DNA polymerases on the move

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12 December 2020

Efficient replication between non-hydrogen-bonded nucleoside shape analogs

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12 December 2020

Klenow fragment-DNA interaction required for the incorporation of nucleotides opposite guanine and O6-methylguanine

1 reference

12 December 2020

The hydration and solvent polarization effects of nucleotide bases

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12 December 2020

A minor groove binding track in reverse transcriptase

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12 December 2020

Identifiers

DOI

10.1021/JA993464+

1 reference

31 July 2017

1 reference

31 July 2017

1 reference