Can gene therapy overcome the problem of hypoxia in radiotherapy? (Q34157875)

31 July 2017

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title

Can gene therapy overcome the problem of hypoxia in radiotherapy? (English)

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adaptive radiation therapy

31 July 2017

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2

Patterson AV

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31 July 2017

Greco O

1

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31 July 2017

Dachs GU

series ordinal

3

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31 July 2017

publication date

1 September 2000

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Journal of Radiation Research

31 July 2017

published in

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31 July 2017

volume

41

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31 July 2017

issue

3

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31 July 2017

page(s)

201-212

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Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

31 July 2017

cites work

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Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment

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Colonisation of Clostridium in the body is restricted to hypoxic and necrotic areas of tumours.

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The macrophage - a novel system to deliver gene therapy to pathological hypoxia

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Microenvironmental control of gene expression: implications for tumor angiogenesis, progression, and metastasis

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The molecular basis of the hypoxia response pathway: tumour hypoxia as a therapy target

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A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension

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Characterization of physiologically regulated vectors for the treatment of ischemic disease

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An adenoviral vector regulated by hypoxia for the treatment of ischaemic disease and cancer

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21 January 2018

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Hypoxic regulation of vascular endothelial growth factor mRNA stability requires the cooperation of multiple RNA elements

21 January 2018

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21 January 2018

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Bystander effects of different enzyme-prodrug systems for cancer gene therapy depend on different pathways for intercellular transfer of toxic metabolites, a factor that will govern clinical choice of appropriate regimes

21 January 2018

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Immune system in suicide-gene therapy

21 January 2018

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The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metabolite

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Molecular chemotherapy for breast cancer

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Chemotherapy as an adjunct to radiation in the treatment of squamous cell carcinoma of the head and neck: results of the Yale Mitomycin Randomized Trials

21 January 2018

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Single-arm, open-label phase II study of intravenously administered tirapazamine and radiation therapy for glioblastoma multiforme

21 January 2018

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The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954.

21 January 2018

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Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069

21 January 2018

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Targeting gene expression to hypoxic tumor cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1269/JRR.41.201

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31 July 2017

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