PrPC, the Cellular Isoform of the Human Prion Protein, Is a Novel Biomarker of HIV-Associated Neurocognitive Impairment and Mediates Neuroinflammation (Q34162407)

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scientific article published on August 19, 2010

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English	PrPC, the Cellular Isoform of the Human Prion Protein, Is a Novel Biomarker of HIV-Associated Neurocognitive Impairment and Mediates Neuroinflammation	scientific article published on August 19, 2010

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scholarly article

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Europe PubMed Central

PubMed publication ID

31 July 2017

PrPC, the cellular isoform of the human prion protein, is a novel biomarker of HIV-associated neurocognitive impairment and mediates neuroinflammation (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PrPC, the Cellular Isoform of the Human Prion Protein, Is a Novel Biomarker of HIV-Associated Neurocognitive Impairment and Mediates Neuroinflammation (English)

1 reference

10.2353/AJPATH.2010.091006

https://api.crossref.org/works/10.2353/AJPATH.2010.091006

19 June 2024

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prion protein family

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3

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Susan Morgello

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Europe PubMed Central

PubMed publication ID

31 July 2017

author name string

Toni K. Roberts

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724601

19 June 2024

Eliseo A. Eugenin

2

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19 June 2024

Janice E. Clements

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19 June 2024

M. Christine Zink

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19 June 2024

Joan W. Berman

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19 June 2024

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19 August 2010

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31 July 2017

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http://ajp.amjpathol.org/article/S0002944010602362/pdf

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19 June 2024

http://ajp.amjpathol.org/cgi/content/abstract/177/4/1848

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19 June 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20724601/pdf/?tool=EBI

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19 June 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20724601/?tool=EBI

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19 June 2024

https://europepmc.org/articles/PMC2947280

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19 June 2024

https://europepmc.org/articles/PMC2947280?pdf=render

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724601

19 June 2024

https://doi.org/10.2353/ajpath.2010.091006

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20724601

19 June 2024

https://api.elsevier.com/content/article/PII:S0002944010602362?httpAccept=text/xml

1 reference

10.2353/AJPATH.2010.091006

https://api.crossref.org/works/10.2353/AJPATH.2010.091006

19 June 2024

https://api.elsevier.com/content/article/PII:S0002944010602362?httpAccept=text/plain

1 reference

10.2353/AJPATH.2010.091006

https://api.crossref.org/works/10.2353/AJPATH.2010.091006

19 June 2024

The American Journal of Pathology

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

177

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

1848-1860

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Mechanisms of HIV-tat-induced phosphorylation of N-methyl-D-aspartate receptor subunit 2A in human primary neurons: implications for neuroAIDS pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Cliniconeuropathologic correlates of human immunodeficiency virus in the era of antiretroviral therapy

1 reference

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5 July 2018

Coordinated regulation of SIV replication and immune responses in the CNS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Astrocyte- and endothelial-targeted CCL2 conditional knockout mice: critical tools for studying the pathogenesis of neuroinflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Involvement of TRPC channels in CCL2-mediated neuroprotection against tat toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

The accelerated simian immunodeficiency virus macaque model of human immunodeficiency virus-associated neurological disease: from mechanism to treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Biomarkers of HIV related central nervous system disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Gap junctions mediate human immunodeficiency virus-bystander killing in astrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Updated research nosology for HIV-associated neurocognitive disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Cellular prion protein interaction with vitronectin supports axonal growth and is compensated by integrins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

The interaction between prion protein and laminin modulates memory consolidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Prevalence and risk factors for human immunodeficiency virus-associated neurocognitive impairment, 1996 to 2002: results from an urban observational cohort

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

The impact of HIV-associated neuropsychological impairment on everyday functioning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Neuropsychiatric impact of hepatitis C on advanced HIV

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Prion protein is a component of the multimolecular signaling complex involved in T cell activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Chemokine-dependent mechanisms of leukocyte trafficking across a model of the blood–brain barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

A novel simian immunodeficiency virus model that provides insight into mechanisms of human immunodeficiency virus central nervous system disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Cellular prion protein transduces neuroprotective signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Cellular prion protein binds laminin and mediates neuritogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

High viral load in the cerebrospinal fluid and brain correlates with severity of simian immunodeficiency virus encephalitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Pathogenesis of SIV encephalitis. Selection and replication of neurovirulent SIV

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Localization of monocyte chemoattractant peptide-1 expression in the central nervous system in experimental autoimmune encephalomyelitis and trauma in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

HIV-1 infection of the developing nervous system: central role of astrocytes in pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Evolution of Neuropathologic Abnormalities Associated with Blood-Brain Barrier Breakdown in Transgenic Mice Expressing lnterleukin-6 in Astrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Scrapie prion protein contains a phosphatidylinositol glycolipid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

5 July 2018

Total prion protein levels in the cerebrospinal fluid are reduced in patients with various neurological disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Regulation of focal adhesion formation and filopodia extension by the cellular prion protein (PrPC).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Cellular prion protein is increased in the plasma and peri-infarcted brain tissue after acute stroke.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Junctional expression of the prion protein PrPC by brain endothelial cells: a role in trans-endothelial migration of human monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Interaction of cellular prion and stress-inducible protein 1 promotes neuritogenesis and neuroprotection by distinct signaling pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Expression of cellular prion protein in the frontal and occipital lobe in Alzheimer's disease, diffuse Lewy body disease, and in normal brain: an immunohistochemical study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Cerebrospinal fluid markers that predict SIV CNS disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Upregulation of cellular prion protein (PrPc) after focal cerebral ischemia and influence of lesion severity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

In situ hybridization analysis of PrP mRNA in human CNS tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

PrP fragment 106-126 is toxic to cerebral endothelial cells expressing PrP(C).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Differential constitutive and activation-dependent expression of prion protein in human peripheral blood leucocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

The relationship between employment and neuropsychological impairment in HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Astrocytic glutamate uptake and prion protein expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Microglial expression of the prion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

Elevated alpha-tumor necrosis factor levels in spinal fluid from HIV-1-infected patients with central nervous system involvement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947280

28 October 2018

The normal cellular form of prion protein modulates T cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/20724601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cellular prion protein modulates phagocytosis and inflammatory response

1 reference

https://pubmed.ncbi.nlm.nih.gov/20724601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 and granulocyte macrophage-csf in the cerebrospinal fluid from hiv infected subjects with involvement of the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/20724601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in blood-brain barrier glucose transport in SIV-infected macaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/20724601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prion protein immunoreactivity in brain samples from an unselected autopsy population: findings in 200 consecutive cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20724601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-associated neurologic disease incidence changes:: Multicenter AIDS Cohort Study, 1990-1998

1 reference

https://pubmed.ncbi.nlm.nih.gov/20724601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunochemical determination of cellular prion protein in plasma from healthy subjects and patients with sporadic CJD or other neurologic diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20724601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Marked increase of neuronal prion protein immunoreactivity in Alzheimer's disease and human prion diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20724601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical confirmation of the American Academy of Neurology algorithm for HIV-1-associated cognitive/motor disorder. The Dana Consortium on Therapy for HIV Dementia and Related Cognitive Disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/20724601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes to AIDS dementia complex in the era of highly active antiretroviral therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20724601

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2353/AJPATH.2010.091006

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

ResearchGate publication ID

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