Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule. (Q34169482)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9826589%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

title

Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule (English)

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6 December 2019

4

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6 December 2019

author name string

J L Penzotti

series ordinal

1

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6 December 2019

H A Fozzard

series ordinal

2

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6 December 2019

G M Lipkind

series ordinal

3

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6 December 2019

language of work or name

English

0 references

publication date

1 December 1998

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6 December 2019

number of pages

11

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based on heuristic

inferred from page(s)

published in

Biophysical Journal

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6 December 2019

volume

75

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6 December 2019

issue

6

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6 December 2019

page(s)

2647-2657

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On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel. Effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2+ and H+, and molecular sieving

6 December 2019

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Altered ionic selectivity of the sodium channel revealed by cysteine mutations within the pore

5 July 2018

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5 July 2018

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On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel

5 July 2018

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Structure of the sodium channel pore revealed by serial cysteine mutagenesis.

5 July 2018

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Specificity for block by saxitoxin and divalent cations at a residue which determines sensitivity of sodium channel subtypes to guanidinium toxins

5 July 2018

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A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

5 July 2018

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Post-repolarization block of cloned sodium channels by saxitoxin: the contribution of pore-region amino acids

5 July 2018

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The microI skeletal muscle sodium channel: mutation E403Q eliminates sensitivity to tetrodotoxin but not to mu-conotoxins GIIIA and GIIIB.

5 July 2018

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The saxitoxin/tetrodotoxin binding site on cloned rat brain IIa Na channels is in the transmembrane electric field

5 July 2018

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Differential effects of sulfhydryl reagents on saxitoxin and tetrodotoxin block of voltage-dependent Na channels

5 July 2018

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Influence of protein surface charge on the bimolecular kinetics of a potassium channel peptide inhibitor

5 July 2018

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Structure and function of voltage-gated ion channels

5 July 2018

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Voltage-dependent block by saxitoxin of sodium channels incorporated into planar lipid bilayers

5 July 2018

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Neurotoxins that Act on Voltage-Sensitive Sodium Channels in Excitable Membranes

5 July 2018

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Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins

5 July 2018

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Batrachotoxin-activated Na+ channels in planar lipid bilayers. Competition of tetrodotoxin block by Na+

5 July 2018

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Structural determinants of the affinity of saxitoxin for neuronal sodium channels. Electrophysiological studies on frog peripheral nerve

5 July 2018

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Mapping the transition state and pathway of protein folding by protein engineering

5 July 2018

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Primary structure and functional expression of a mammalian skeletal muscle sodium channel

5 July 2018

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A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II.

5 July 2018

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5 July 2018

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Kinetic basis for insensitivity to tetrodotoxin and saxitoxin in sodium channels of canine heart and denervated rat skeletal muscle

5 July 2018

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Batrachotoxin-modified sodium channels in planar lipid bilayers. Characterization of saxitoxin- and tetrodotoxin-induced channel closures

5 July 2018

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Kinetics of TTX-STX block of sodium channels.

5 July 2018

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5 July 2018

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Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins

5 July 2018

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5 July 2018

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5 July 2018

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A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties

5 July 2018

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5 July 2018

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5 July 2018

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Actions of decarbamoyloxysaxitoxin and decarbamoylneosaxitoxin on the frog skeletal muscle fiber

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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The receptor for tetrodotoxin and saxitoxin. A structural hypothesis

5 July 2018

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The binding of saxitoxin and tetrodotoxin to excitable tissue

5 July 2018

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5 July 2018

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Characteristics of saxitoxin binding to the sodium channel of sarcolemma isolated from rat skeletal muscle

7 January 2021

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Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis.

5 July 2018

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Control of ion flux and selectivity by negatively charged residues in the outer mouth of rat sodium channels.

28 October 2018

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Two conformational states involved in the use-dependent TTX blockade of human cardiac Na+ channel.

28 October 2018

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Site-directed mutagenesis of the putative pore region of the rat IIA sodium channel.

28 October 2018

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The potencies of synthetic analogues of saxitoxin and the absolute stereoselectivity of decarbamoyl saxitoxin.

28 October 2018

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Active groups of saxitoxin and tetrodotoxin as deduced from actions of saxitoxin analogues on frog muscle and squid axon

28 October 2018

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Voltage-clamp experiments in normal and denervated mammalian skeletal muscle fibres.

28 October 2018

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Structure-activity relations of tetrodotoxin, saxitoxin, and analogues.

28 October 2018

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Isochannels and blocking modes of voltage-dependent sodium channels.

28 October 2018

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Cysteine mapping in the ion selectivity and toxin binding region of the cardiac Na+ channel pore

28 October 2018

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Depth asymmetries of the pore-lining segments of the Na+ channel revealed by cysteine mutagenesis

7 January 2021

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7 January 2021

Identifiers

DOI

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6 December 2019

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6 December 2019

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