Hydroxycarbamide: a user's guide for chronic myeloproliferative disorders. (Q34171747)

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25 January 2020

review article

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title

Hydroxycarbamide: a user's guide for chronic myeloproliferative disorders (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21417854%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

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2

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25 January 2020

author name string

Jerry L Spivak

series ordinal

1

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25 January 2020

publication date

1 March 2011

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Expert Review of Anticancer Therapy

25 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21417854%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

volume

11

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25 January 2020

issue

3

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25 January 2020

page(s)

403-414

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Pharmacokinetics and pharmacodynamics of hydroxyurea

25 January 2020

cites work

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The influence of renal function on hydroxyurea pharmacokinetics in adults with sickle cell disease

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The enzyme ribonucleotide reductase: target for antitumor and anti-HIV therapy

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Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis

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Long-term follow-up of 386 consecutive patients with essential thrombocythemia: safety of cytoreductive therapy

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Anagrelide: 20 years later

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Sustained major molecular response on interferon alpha-2b in two patients with polycythemia vera.

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Frequent reduction or absence of detection of the JAK2-mutated clone in JAK2V617F-positive patients within the first years of hydroxyurea therapy

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Rapid decline of JAK2V617F levels during hydroxyurea treatment in patients with polycythemia vera and essential thrombocythemia

21 January 2018

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Molecular mimicry in the chronic myeloproliferative disorders: reciprocity between quantitative JAK2 V617F and Mpl expression

21 January 2018

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Limited efficacy of hydroxyurea in lowering of the JAK2 V617F allele burden

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Hydroxyurea induced acute elevations in liver function tests

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Hydroxycarbamide associated platelet count oscillations in a patient with polycythaemia vera. A case report and review of the literature

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Hydroxyurea induced oscillations in twelve patients with polycythemia vera.

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Secondary cutaneous effects of hydroxyurea: possible pathogenetic mechanisms

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The cutaneous side-effects of hydroxyurea

21 January 2018

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21 January 2018

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Fulminant bronchiolitis obliterans organizing pneumonia following 2 d of treatment with hydroxyurea, interferon-alpha and oral cytarabine ocfosfate for chronic myelogenous leukemia

21 January 2018

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Hydroxyurea-induced pneumonitis in a patient with chronic idiopathic myelofibrosis after prolonged drug exposure

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Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer

21 January 2018

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Inhibitors of repair DNA synthesis.

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Acute leukemia and myelodysplasia in patients with a Philadelphia chromosome negative chronic myeloproliferative disorder treated with hydroxyurea alone or with hydroxyurea after busulphan

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Acute myeloid leukemia (AML) having evolved from essential thrombocythemia (ET): distinctive chromosome abnormalities in patients treated with pipobroman or hydroxyurea.

21 January 2018

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p53 mediates senescence-like arrest induced by chronic replicational stress

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p53 accumulates but is functionally impaired when DNA synthesis is blocked

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Replicational stress selects for p53 mutation

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Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells

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Characterization of homologous recombination induced by replication inhibition in mammalian cells

21 January 2018

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p53's double life: transactivation-independent repression of homologous recombination.

21 January 2018

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Impaired DNA replication within progenitor cell pools promotes leukemogenesis.

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BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair

21 January 2018

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JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.

21 January 2018

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Long-term incidence of hematological evolution in three French prospective studies of hydroxyurea and pipobroman in polycythemia vera and essential thrombocythemia.

21 January 2018

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Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation.

21 January 2018

1 reference

Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation

21 January 2018

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The effect of hydroxyurea and mitomycin C on sperm motility in mice.

21 January 2018

1 reference

Influence of sickle cell disease and treatment with hydroxyurea on sperm parameters and fertility of human males

21 January 2018

1 reference

Comparative distribution and embryotoxicity of hydroxyurea in pregnant rats and rhesus monkeys

21 January 2018

1 reference

Pregnancy after treatment with hydroxyurea in a patient with primary thrombocythaemia and a history of recurrent abortion

21 January 2018

1 reference

Acute leukemia in polycythemia vera: an analysis of 1638 patients enrolled in a prospective observational study

21 January 2018

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AML transformation in 56 patients with Ph- MPD in two well defined populations.

21 January 2018

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Second malignancies in essential thrombocythemia (ET): a retrospective analysis of 331 patients with long-term follow-up from a single institution.

21 January 2018

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Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera

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