Rational design and characterization of the novel, broad and potent bispecific HIV-1 neutralizing antibody iMabm36. (Q34174815)

31 July 2017

title

Rational design and characterization of the novel, broad and potent bispecific HIV-1 neutralizing antibody iMabm36. (English)

1 reference

31 July 2017

1 reference

8

Qihan Li

1 reference

31 July 2017

Ming Sun

1

1 reference

31 July 2017

Craig S Pace

2

1 reference

31 July 2017

Xin Yao

3

1 reference

31 July 2017

Faye Yu

4

1 reference

31 July 2017

Neal N Padte

5

1 reference

31 July 2017

Yaoxing Huang

6

1 reference

31 July 2017

Michael S Seaman

7

1 reference

31 July 2017

David D Ho

9

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31 July 2017

language of work or name

English

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publication date

1 August 2014

1 reference

Journal of Acquired Immune Deficiency Syndromes

31 July 2017

published in

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31 July 2017

volume

66

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31 July 2017

issue

5

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31 July 2017

page(s)

473-483

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HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

31 July 2017

cites work

1 reference

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Epitope mapping of M36, a human antibody domain with potent and broad HIV-1 inhibitory activity

28 July 2018

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Molecular structures of trimeric HIV-1 Env in complex with small antibody derivatives.

28 July 2018

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Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

28 July 2018

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HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.

28 July 2018

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Increasing the potency and breadth of an HIV antibody by using structure-based rational design

28 July 2018

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A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

28 July 2018

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28 July 2018

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Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures

28 July 2018

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28 July 2018

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Bifunctional fusion proteins of the human engineered antibody domain m36 with human soluble CD4 are potent inhibitors of diverse HIV-1 isolates

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target

28 July 2018

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Safety, pharmacokinetics, and antiretroviral activity of multiple doses of ibalizumab (formerly TNX-355), an anti-CD4 monoclonal antibody, in human immunodeficiency virus type 1-infected adults

28 July 2018

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Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers

28 July 2018

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Llama antibody fragments with cross-subtype human immunodeficiency virus type 1 (HIV-1)-neutralizing properties and high affinity for HIV-1 gp120

28 July 2018

1 reference

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Molecular architecture of native HIV-1 gp120 trimers

28 July 2018

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A tyrosine-sulfated peptide derived from the heavy-chain CDR3 region of an HIV-1-neutralizing antibody binds gp120 and inhibits HIV-1 infection

28 July 2018

1 reference

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Epitope mapping and characterization of a novel CD4-induced human monoclonal antibody capable of neutralizing primary HIV-1 strains

28 July 2018

1 reference

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Characterization of CD4-induced epitopes on the HIV type 1 gp120 envelope glycoprotein recognized by neutralizing human monoclonal antibodies

28 July 2018

1 reference

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Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

28 July 2018

1 reference

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The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

28 July 2018

1 reference

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Inhibition of HIV infection by a novel CD4 domain 2-specific monoclonal antibody. Dissecting the basis for its inhibitory effect on HIV-induced cell fusion

28 July 2018

1 reference

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A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells

28 July 2018

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28 July 2018

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Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

28 October 2018

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Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo

28 October 2018

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Anti-CD4 monoclonal antibody ibalizumab exhibits breadth and potency against HIV-1, with natural resistance mediated by the loss of a V5 glycan in envelope.

28 October 2018

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Broad neutralization coverage of HIV by multiple highly potent antibodies

28 October 2018

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Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

28 October 2018

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Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

28 October 2018

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Human monoclonal antibodies and engineered antibody domains as HIV-1 entry inhibitors

28 October 2018

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Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163016

Antiretroviral activity of the anti-CD4 monoclonal antibody TNX-355 in patients infected with HIV type 1.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163016

Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163016

The entry of entry inhibitors: a fusion of science and medicine

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163016

Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163016

A phase I trial with two human monoclonal antibodies (hMAb 2F5, 2G12) against HIV-1.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163016

Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163016

Potent, broad-spectrum inhibition of human immunodeficiency virus type 1 by the CCR5 monoclonal antibody PRO 140

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163016

Post-exposure prophylaxis with human monoclonal antibodies prevented SHIV89.6P infection or disease in neonatal macaques

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24853313

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Fast track for antiretroviral

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24853313

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of a synthetic peptide that mimics an HIV glycoprotein 120 envelope conformational determinant exposed following ligation of glycoprotein 120 by CD4

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24853313

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1097/QAI.0000000000000218

1 reference

31 July 2017

1 reference

31 July 2017

1 reference