Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies (Q34177732)

31 July 2017

title

Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies (English)

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31 July 2017

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Salim S Abdool Karim

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Myron S. Cohen

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Myron S Cohen

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John R Mascola

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Garnett Kelsoe

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Barton F Haynes

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Lynn Morris

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Peter D Kwong

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Ivelin S Georgiev

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Krissey E Lloyd

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Christina Stolarchuk

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Thomas B Kepler

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Scott D Boyd

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S Munir Alam

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M Anthony Moody

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Ruijun Zhang

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Hua-Xin Liao

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Charles Emmanuel Jebaraj Walter

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Emmanuel Walter

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Kara Anasti

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Robert Parks

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Jamie Pritchett

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Rekha Bhaskarabhatla

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Chandri Yandava

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Shelley Stewart

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Erika Solomon

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Emma Friberg

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Xueling Wu

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Han R Altae-Tran

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Andrew Z Fire

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publication date

1 September 2014

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volume

16

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issue

3

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page(s)

304-313

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Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation

31 July 2017

cites work

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5 July 2018

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Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection

5 July 2018

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Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires

5 July 2018

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Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

5 July 2018

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Residue-level prediction of HIV-1 antibody epitopes based on neutralization of diverse viral strains

5 July 2018

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HIV-1 neutralizing antibodies: understanding nature's pathways

5 July 2018

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Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

5 July 2018

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Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion

5 July 2018

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Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies

5 July 2018

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Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

Polyreactive antibodies in adaptive immune responses to viruses

5 July 2018

1 reference

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H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting

5 July 2018

1 reference

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Differential reactivity of germ line allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

Broad neutralization coverage of HIV by multiple highly potent antibodies

5 July 2018

1 reference

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Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals

5 July 2018

1 reference

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Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

5 July 2018

1 reference

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Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody

5 July 2018

1 reference

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Potent and broad neutralization of HIV-1 subtype C by plasma antibodies targeting a quaternary epitope including residues in the V2 loop

5 July 2018

1 reference

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B cell responses to HIV-1 infection and vaccination: pathways to preventing infection

5 July 2018

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Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

5 July 2018

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Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

5 July 2018

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Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing

5 July 2018

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Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies

5 July 2018

1 reference

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Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target

5 July 2018

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In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth

5 July 2018

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Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

5 July 2018

1 reference

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Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

Human immunodeficiency virus type 1 gp41 antibodies that mask membrane proximal region epitopes: antibody binding kinetics, induction, and potential for regulation in acute infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

Masquerading repeats: paralogous pitfalls of the human genome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

Optimal sequence alignment allowing for long gaps.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

Somatic hypermutation in the heavy chain locus correlates with transcription

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4163498

10.1016/J.CHOM.2014.08.006

28 October 2018

Identifiers

DOI

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31 July 2017

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31 July 2017

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