Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation. (Q34179395)

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English	Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.	scientific article

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scholarly article

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29 January 2020

Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation (English)

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29 January 2020

Andrey Nikiforov

1

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29 January 2020

Mathias Ziegler

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29 January 2020

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Christian Dölle

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29 January 2020

Marc Niere

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29 January 2020

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19 April 2011

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29 January 2020

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12

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Journal of Biological Chemistry

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29 January 2020

286

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29 January 2020

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29 January 2020

21767-21778

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29 January 2020

Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool

1 reference

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28 July 2018

Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases

1 reference

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28 July 2018

Wallerian degeneration, wld(s), and nmnat

1 reference

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The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways

1 reference

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28 July 2018

Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside.

1 reference

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Molecular identification and functional characterization of Arabidopsis thaliana mitochondrial and chloroplastic NAD+ carrier proteins

1 reference

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28 July 2018

The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors

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SIRT1 and insulin resistance

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SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle

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28 July 2018

Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis

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Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1

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28 July 2018

Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis

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28 July 2018

Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism

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28 July 2018

Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5

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28 July 2018

Enzymology of mammalian NAD metabolism in health and disease

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28 July 2018

Characterization of NAD uptake in mammalian cells

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28 July 2018

Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix

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28 July 2018

The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.

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28 July 2018

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

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28 July 2018

NAD kinase levels control the NADPH concentration in human cells

1 reference

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28 July 2018

Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells

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28 July 2018

Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

1 reference

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28 July 2018

Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1

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Regulation of calcium signalling by adenine-based second messengers

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28 July 2018

NAD+ metabolism in health and disease

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28 July 2018

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

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28 July 2018

Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

1 reference

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28 July 2018

The Nudix hydrolase superfamily

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28 July 2018

Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae

1 reference

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28 July 2018

Poly(ADP-ribose). The most elaborate metabolite of NAD+.

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28 July 2018

Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

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28 July 2018

The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

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28 July 2018

Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans

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28 July 2018

Biosynthesis of diphosphopyridine nucleotide. II. Enzymatic aspects

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28 July 2018

Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein

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Regulation of corepressor function by nuclear NADH.

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28 July 2018

Extracellular metabolism of ATP and other nucleotides

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28 July 2018

Connexin 43 hemi channels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells

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28 July 2018

Nucleoside and nucleobase transport systems of mammalian cells

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28 July 2018

Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration.

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Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo

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28 October 2018

Application of a coupled enzyme assay to characterize nicotinamide riboside kinases

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28 October 2018

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28 October 2018

The new life of a centenarian: signalling functions of NAD(P).

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28 October 2018

Hydrolysis of diadenosine polyphosphates by nucleotide pyrophosphatases/phosphodiesterases

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Pathophysiological relevance of mitochondria in NAD(+) metabolism.

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28 October 2018

Metabolic fate of extracellular NAD in human skin fibroblasts

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28 October 2018

An ecto-nucleotide pyrophosphatase is one of the main enzymes involved in the extracellular metabolism of ATP in rat C6 glioma.

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28 October 2018

Visualization of subcellular NAD pools and intra-organellar protein localization by poly-ADP-ribose formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21504897

12 December 2020

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10.1074/JBC.M110.213298

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29 January 2020

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29 January 2020

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Europe PubMed Central

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29 January 2020

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