Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. (Q34180241)

31 July 2017

title

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. (English)

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31 July 2017

J Chen

1

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31 July 2017

J Xie

2

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31 July 2017

Z Jiang

3

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31 July 2017

B Wang

4

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31 July 2017

Y Wang

5

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31 July 2017

X Hu

6

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31 July 2017

language of work or name

English

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publication date

25 April 2011

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31 July 2017

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31 July 2017

volume

30

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31 July 2017

issue

42

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31 July 2017

page(s)

4297-4306

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Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes

31 July 2017

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

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Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

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Why do cancers have high aerobic glycolysis?

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Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis

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Allosteric regulation of pyruvate kinase M2 isozyme involves a cysteine residue in the intersubunit contact

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The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate

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Antitumor activities of a newly synthesized shikonin derivative, 2-hyim-DMNQ-S-33.

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Honokiol induces a necrotic cell death through the mitochondrial permeability transition pore

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Design, synthesis, and biological evaluation of N-carboxyphenylpyrrole derivatives as potent HIV fusion inhibitors targeting gp41

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Beta-hydroxyisovalerylshikonin induces apoptosis in human leukemia cells by inhibiting the activity of a polo-like kinase 1 (PLK1).

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A shikonin derivative, ??-hydroxyisovalerylshikonin, is an ATP-non-competitive inhibitor of protein tyrosine kinases

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The monomer of pyruvate kinase, subtype M1, is both a kinase and a cytosolic thyroid hormone binding protein

21 January 2018

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Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein

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Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation

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Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply

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Identification of small molecule inhibitors of pyruvate kinase M2

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On the Origin of Cancer Cells

21 January 2018

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Naturally-occurring shikonin analogues--a class of necroptotic inducers that circumvent cancer drug resistance

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Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo.

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Acylshikonin analogues: synthesis and inhibition of DNA topoisomerase-I

21 January 2018

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Shikonin circumvents cancer drug resistance by induction of a necroptotic death

31 March 2020

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Studies on pyruvate kinase (PK) deficiency. II. Electrophoretic, kinetic and immunological studies on pyruvate kinase of erythrocytes and other tissues.

31 March 2020

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The Chemistry and Biology of Alkannin, Shikonin, and Related Naphthazarin Natural Products

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2011.137

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Dimensions Publication ID

31 July 2017

1019174410

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