p27 as a target for cancer therapeutics (Q34181774)

31 July 2017

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title

p27 as a target for cancer therapeutics (English)

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31 July 2017

3

Carlos Cordon-Cardo

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31 July 2017

Stacy W Blain

1

1 reference

PubMed ID

12620406

31 July 2017

Howard I Scher

series ordinal

2

1 reference

PubMed ID

12620406

31 July 2017

Andrew Koff

series ordinal

4

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31 July 2017

1 February 2003

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31 July 2017

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31 July 2017

3

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31 July 2017

2

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31 July 2017

111-115

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Inhibition of cyclin-dependent kinase activity and induction of apoptosis by preussin in human tumor cells

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1).

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

p27 deficiency desensitizes Rb-/- cells to signals that trigger apoptosis during pituitary tumor development

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Inhibin and p27 interact to regulate gonadal tumorigenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

E1A signaling to p53 involves the p19(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Skp2 is oncogenic and overexpressed in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Expression and subcellular localization of the cyclin-dependent kinase inhibitor p27(Kip1) in epithelial ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Induction of cell cycle arrest and apoptosis in human prostate carcinoma cells by a recombinant adenovirus expressing p27(Kip1).

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Role of the F-box protein Skp2 in lymphomagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

TGFbeta signaling in growth control, cancer, and heritable disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Ras and Rho regulation of the cell cycle and oncogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

The RB and p53 pathways in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Overexpression of p27(Kip1) induces growth arrest and apoptosis in an oral cancer cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900026-6

7 January 2021

10.1016/S1535-6108(03)00026-6

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

12620406