α-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration (Q34183367)

31 July 2017

title

α-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration (English)

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31 July 2017

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Oleg S Gorbatyuk

1

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31 July 2017

Shoudong Li

2

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31 July 2017

Frederic Nha Nguyen

3

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31 July 2017

Fredric P Manfredsson

4

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31 July 2017

Galina Kondrikova

5

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31 July 2017

Layla F Sullivan

6

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31 July 2017

Craig Meyers

7

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31 July 2017

Weijun Chen

8

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31 July 2017

Ronald J Mandel

9

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31 July 2017

Nicholas Muzyczka

10

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31 July 2017

publication date

27 July 2010

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31 July 2017

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31 July 2017

volume

18

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31 July 2017

issue

10

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31 July 2017

page(s)

1758-1768

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In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration

31 July 2017

cites work

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5 July 2018

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5 July 2018

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Evidence that alpha-synuclein does not inhibit phospholipase D

5 July 2018

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5 July 2018

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Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi

5 July 2018

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The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

5 July 2018

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Phospholipase D: a lipid centric review

5 July 2018

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Functions and pathophysiological roles of phospholipase D in the brain

5 July 2018

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Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells

5 July 2018

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D3 dopamine receptor activates phospholipase D through a pertussis toxin-insensitive pathway

5 July 2018

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Ral and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor endocytosis

5 July 2018

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Transduction profiles of recombinant adeno-associated virus vectors derived from serotypes 2 and 5 in the nigrostriatal system of rats

5 July 2018

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Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis

5 July 2018

1 reference

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D2s dopamine receptor mediates phospholipase D and antiproliferation

5 July 2018

1 reference

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Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors

5 July 2018

1 reference

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Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

5 July 2018

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alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

5 July 2018

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alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells

5 July 2018

1 reference

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alpha-Synuclein forms a complex with transcription factor Elk-1.

5 July 2018

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The D2s dopamine receptor stimulates phospholipase D activity: a novel signaling pathway for dopamine.

5 July 2018

1 reference

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Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

5 July 2018

1 reference

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Identification of a phosphoinositide binding motif that mediates activation of mammalian and yeast phospholipase D isoenzymes

5 July 2018

1 reference

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Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins

5 July 2018

1 reference

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Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951555

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

5 July 2018

1 reference

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Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951555

Accumulation of phosphorylated alpha-synuclein in dopaminergic neurons of transgenic mice that express human alpha-synuclein

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951555

The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951555

Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951555

Structural determinants of PLD2 inhibition by alpha-synuclein

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951555

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951555

Parkinsonian motor deficits are reflected by proportional A9/A10 dopamine neuron degeneration in the rat.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951555

Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951555

Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951555

28 October 2018

Identifiers

DOI

10.1038/MT.2010.137

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31 July 2017

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31 July 2017

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