The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro (Q34187610)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397687%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro (English)

1 reference

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25 January 2020

2

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25 January 2020

author name string

Elisabetta Tabolacci

1

1 reference

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25 January 2020

Baltazar Gomez-Mancilla

3

1 reference

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25 January 2020

Fabrizio Gasparini

4

1 reference

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25 January 2020

Giovanni Neri

5

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25 January 2020

publication date

7 March 2012

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25 January 2020

1 reference

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25 January 2020

volume

13

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25 January 2020

page(s)

13

1 reference

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Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056.

25 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320553

A pilot open label, single dose trial of fenobam in adults with fragile X syndrome.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320553

Epigenetic analysis reveals a euchromatic configuration in the FMR1 unmethylated full mutations.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320553

Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320553

Correction of fragile X syndrome in mice.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320553

Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320553

The mGluR theory of fragile X mental retardation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320553

The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320553

Quantitative analysis of DNA demethylation and transcriptional reactivation of the FMR1 gene in fragile X cells treated with 5-azadeoxycytidine

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320553

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320553

Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP.

28 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1471-2350-13-13

AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1471-2350-13-13

AFQ056 treatment of levodopa-induced dyskinesias: results of 2 randomized controlled trials

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22397687

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1471-2350-13-13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397687%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

25 January 2020

1020389248

0 references

Fatcat ID

release_mte4y3jwszb2hmbfki33zjw5am

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/mte4y3jwszb2hmbfki33zjw5am

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

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25 January 2020

PubMed publication ID

22397687

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397687%20AND%20SRC:MED&resulttype=core&format=json