Identification of Essential Residues Involved in the Allosteric Modulation of the Human A3Adenosine Receptor (Q34190610)

31 July 2017

Identification of essential residues involved in the allosteric modulation of the human A(3) adenosine receptor (English)

1 reference

31 July 2017

Identification of Essential Residues Involved in the Allosteric Modulation of the Human A3Adenosine Receptor (English)

1 reference

Crossref

https://api.crossref.org/works/10.1124/MOL.63.5.1021

24 December 2023

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https://api.crossref.org/works/10.1124/MOL.63.5.1021

24 December 2023

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https://api.crossref.org/works/10.1124/MOL.63.5.1021

24 December 2023

6

Kenneth A. Jacobson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695530

24 December 2023

author name string

Zhan-Guo Gao

1

1 reference

31 July 2017

Soo-Kyung Kim

2

1 reference

31 July 2017

Aishe Chen

4

1 reference

31 July 2017

Ariel S. Gross

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695530

24 December 2023

Joshua B. Blaustein

5

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24 December 2023

language of work or name

English

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National Center for Biotechnology Information

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24 December 2023

publication date

1 May 2003

1 reference

full work available at URL

31 July 2017

https://europepmc.org/articles/pmc4367541?pdf=render

file format

Portable Document Format

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695530

https://europepmc.org/articles/PMC4367541

24 December 2023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695530

https://europepmc.org/articles/PMC4367541?pdf=render

24 December 2023

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695530

https://syndication.highwire.org/content/doi/10.1124/mol.63.5.1021

24 December 2023

1 reference

Crossref

https://api.crossref.org/works/10.1124/MOL.63.5.1021

24 December 2023

published in

Molecular Pharmacology

1 reference

31 July 2017

63

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31 July 2017

5

1 reference

31 July 2017

1021-1031

1 reference

Molecular Architecture of G Protein-Coupled Receptors.

31 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

G protein-coupled receptor allosterism and complexing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

[(3)H]8-Ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one ([(3)H]PSB-11), a novel high-affinity antagonist radioligand for human A(3) adenosine receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Allosteric modulation of A(3) adenosine receptors by a series of 3-(2-pyridinyl)isoquinoline derivatives

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Multiple allosteric sites on muscarinic receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Differential effects of the allosteric enhancer (2-amino-4,5-dimethyl-trienyl)[3-trifluoromethyl) phenyl]methanone (PD81,723) on agonist and antagonist binding and function at the human wild-type and a mutant (T277A) adenosine A1 receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

The binding-site crevice of the D4 dopamine receptor is coupled to three distinct sites of allosteric modulation

5 July 2018

1 reference

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Cooperative multi-modal sensing and therapeutic implications of the extracellular Ca(2+) sensing receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Crystal structure of rhodopsin: A G protein-coupled receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

TinyGRAP database: a bioinformatics tool to mine G-protein-coupled receptor mutant data.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Allosteric interactions at muscarinic cholinoceptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Site-directed mutagenesis of the human A1 adenosine receptor: influences of acidic and hydroxy residues in the first four transmembrane domains on ligand binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Mutational analysis of muscarinic acetylcholine receptors: structural basis of ligand/receptor/G protein interactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Role of acidic amino acids in the allosteric modulation by gallamine of antagonist binding at the m2 muscarinic acetylcholine receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

5 July 2018

GABAA receptor channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Use of eukaryotic expression technology in the functional analysis of cloned genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Differential allosteric modulation by amiloride analogues of agonist and antagonist binding at A(1) and A(3) adenosine receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Galantamine for Alzheimer's disease.

28 October 2018

1 reference

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Deoxamuscaroneoxime derivatives as useful muscarinic agonists to explore the muscarinic subsite: demox, a modulator of orthosteric and allosteric sites at cardiac muscarinic M2 receptors

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Allosteric site on muscarinic acetylcholine receptors: a single amino acid in transmembrane region 7 is critical to the subtype selectivities of caracurine V derivatives and alkane-bisammonium ligands

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Modeling and mutational analysis of a putative sodium-binding pocket on the dopamine D2 receptor

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Agonist binding and function at the human alpha(2A)-adrenoceptor: allosteric modulation by amilorides.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

A fast new approach to pharmacophore mapping and its application to dopaminergic and benzodiazepine agonists.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367541

Site-directed mutagenesis reveals two epitopes involved in the subtype selectivity of the allosteric interactions of gallamine at muscarinic acetylcholine receptors

28 October 2018

1 reference

12 December 2020

Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis

1 reference

12 December 2020

Homology modeling of the dopamine D2 receptor and its testing by docking of agonists and tricyclic antagonists

1 reference

12 December 2020

Pivotal role of an aspartate residue in sodium sensitivity and coupling to G proteins of neurotensin receptors

1 reference

12 December 2020

Allosteric modulation of A2A adenosine receptors by amiloride analogues and sodium ions

1 reference

12 December 2020

An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium

1 reference

12 December 2020

Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

36

1 reference

Crossref

https://api.crossref.org/works/10.1124/MOL.63.5.1021

24 December 2023

Identifiers

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31 July 2017

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31 July 2017

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