Perifosine induces protective autophagy and upregulation of ATG5 in human chronic myelogenous leukemia cells in vitro (Q34190803)

31 July 2017

Perifosine induces protective autophagy and upregulation of ATG5 in human chronic myelogenous leukemia cells in vitro (English)

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31 July 2017

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1 reference

Yin Tong

1

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31 July 2017

Yan-yan Liu

series ordinal

2

1 reference

31 July 2017

Liang-shun You

series ordinal

3

1 reference

31 July 2017

Wen-bin Qian

series ordinal

4

1 reference

31 July 2017

12 March 2012

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Acta Pharmacologica Sinica

31 July 2017

1 reference

31 July 2017

33

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31 July 2017

4

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31 July 2017

542-550

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describes a project that uses

31 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4003362/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/aps.2011.192

0 references

cites work

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The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells

5 July 2018

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Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells

5 July 2018

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In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine

5 July 2018

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Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy

5 July 2018

1 reference

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Control of basal autophagy by calpain1 mediated cleavage of ATG5

5 July 2018

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Discovery of Atg5/Atg7-independent alternative macroautophagy

5 July 2018

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Inhibition of autophagy induced by overexpression of mda-7/interleukin-24 strongly augments the antileukemia activity in vitro and in vivo

5 July 2018

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Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells

5 July 2018

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Chronic myeloid leukemia stem cells

5 July 2018

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Translation of the Philadelphia chromosome into therapy for CML.

5 July 2018

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AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines

5 July 2018

1 reference

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Non-canonical autophagy: an exception or an underestimated form of autophagy?

5 July 2018

1 reference

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

5 July 2018

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Molecular biology of bcr-abl1-positive chronic myeloid leukemia

5 July 2018

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The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias

5 July 2018

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Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

5 July 2018

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Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells

5 July 2018

1 reference

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Autophagy in the Pathogenesis of Disease

5 July 2018

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Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations

5 July 2018

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Role of autophagy in cancer

5 July 2018

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Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: implications for neurodegeneration and cell death

5 July 2018

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The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway

5 July 2018

1 reference

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Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance

5 July 2018

1 reference

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The anticancer drug imatinib induces cellular autophagy.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4003362

Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4003362

BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4003362

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

5 July 2018

1 reference

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Tumor and normal tissue pharmacokinetics of perifosine, an oral anti-cancer alkylphospholipid

5 July 2018

1 reference

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Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4003362

The development of imatinib as a therapeutic agent for chronic myeloid leukemia

5 July 2018

1 reference

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Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8

5 July 2018

1 reference

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Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway

5 July 2018

1 reference

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

5 July 2018

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

5 July 2018

1 reference

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Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway

5 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4003362

5 July 2018

https://api.crossref.org/works/10.1038%2FAPS.2011.192

inferred from DOI database lookup

7 January 2021

based on heuristic

Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4003362

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4003362

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4003362

High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia.

5 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.192

Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.192

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.192

Involvement of Akt kinase in the action of STI571 on chronic myelogenous leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.192

Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4003362

Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the APEX trial

28 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.192

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/APS.2011.192

1 reference

Dimensions Publication ID

31 July 2017

0 references

1 reference

31 July 2017

1 reference