Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs (Q34190825)

31 July 2017

Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs (English)

1 reference

31 July 2017

Jae-Yeol Kim

1

1 reference

31 July 2017

Bong-Kyu Choi

2

1 reference

31 July 2017

Mal-Gi Choi

3

1 reference

31 July 2017

Sun-Ae Kim

4

1 reference

31 July 2017

Ying Lai

5

1 reference

31 July 2017

Yeon-Kyun Shin

6

1 reference

31 July 2017

Nam Ki Lee

7

1 reference

31 July 2017

language of work or name

English

0 references

publication date

9 March 2012

1 reference

31 July 2017

1 reference

31 July 2017

31

1 reference

31 July 2017

9

1 reference

31 July 2017

2144-2155

1 reference

Membrane protein sequestering by ionic protein-lipid interactions

31 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Mechanism and function of synaptotagmin-mediated membrane apposition

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Docking, not fusion, as the rate-limiting step in a SNARE-driven vesicle fusion assay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Dynamic Ca2+-dependent stimulation of vesicle fusion by membrane-anchored synaptotagmin 1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Discrimination between docking and fusion of liposomes reconstituted with neuronal SNARE-proteins using FCS.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Autapses and networks of hippocampal neurons exhibit distinct synaptic transmission phenotypes in the absence of synaptotagmin I.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Membrane fusion: grappling with SNARE and SM proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Phosphatidylinositol 4,5-bisphosphate regulates SNARE-dependent membrane fusion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

5 July 2018

Synaptic vesicle fusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Cross-linking of phospholipid membranes is a conserved property of calcium-sensitive synaptotagmins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

How does synaptotagmin trigger neurotransmitter release?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

SNARE-catalyzed fusion events are regulated by Syntaxin1A-lipid interactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Synaptotagmin C2A loop 2 mediates Ca2+-dependent SNARE interactions essential for Ca2+-triggered vesicle exocytosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

How synaptotagmin promotes membrane fusion.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Multiple intermediates in SNARE-induced membrane fusion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Asymmetric phospholipid distribution drives in vitro reconstituted SNARE-dependent membrane fusion.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

C2B polylysine motif of synaptotagmin facilitates a Ca2+-independent stage of synaptic vesicle priming in vivo.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

SNAREs--engines for membrane fusion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Conserved prefusion protein assembly in regulated exocytosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

SNARE-driven, 25-millisecond vesicle fusion in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Phosphatidylinositol phosphate kinase type I gamma regulates dynamics of large dense-core vesicle fusion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Accurate FRET measurements within single diffusing biomolecules using alternating-laser excitation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Single molecule observation of liposome-bilayer fusion thermally induced by soluble N-ethyl maleimide sensitive-factor attachment protein receptors (SNAREs)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

The synaptic vesicle cycle

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Fluorescence-aided molecule sorting: analysis of structure and interactions by alternating-laser excitation of single molecules

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Imaging single membrane fusion events mediated by SNARE proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Calcium-independent stimulation of membrane fusion and SNAREpin formation by synaptotagmin I.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Reconstituted syntaxin1a/SNAP25 interacts with negatively charged lipids as measured by lateral diffusion in planar supported bilayers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Synaptotagmin I functions as a calcium regulator of release probability

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

SNAREpins: minimal machinery for membrane fusion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Timing of neurotransmission at fast synapses in the mammalian brain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Synaptic transmission persists in synaptotagmin mutants of Drosophila

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

Synaptotagmin: a calcium sensor on the synaptic vesicle surface.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3343461

The activation of exocytotic sites by the formation of phosphatidylinositol 4,5-bisphosphate microdomains at syntaxin clusters

5 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.57

PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.57

Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.57

Calcium influx and transmitter release in a fast CNS synapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.57

ATP-dependent inositide phosphorylation required for Ca2+-activated secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.57

A Pleckstrin Homology Domain Specific for Phosphatidylinositol 4,5-Bisphosphate (PtdIns-4,5-P2) and Fused to Green Fluorescent Protein Identifies Plasma Membrane PtdIns-4,5-P2as Being Important in Exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.57

Plasmalemmal phosphatidylinositol-4,5-bisphosphate level regulates the releasable vesicle pool size in chromaffin cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.57

Dual roles of the C2B domain of synaptotagmin I in synchronizing Ca2+-dependent neurotransmitter release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.57

Synaptotagmin I synchronizes transmitter release in mouse hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.57

The synaptic SNARE complex is a parallel four-stranded helical bundle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.57

Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.57

Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.57

Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.57

Intracellular calcium dependence of transmitter release rates at a fast central synapse

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22407297

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

N- to C-Terminal SNARE Complex Assembly Promotes Rapid Membrane Fusion

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22407297

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The membrane-dipped neuronal SNARE complex: a site-directed spin labeling electron paramagnetic resonance study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22407297

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2012.57

1 reference

31 July 2017

1 reference

31 July 2017

1 reference