Antigen processing by the proteasome (Q34193262)

31 July 2017

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title

Antigen processing by the proteasome (English)

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31 July 2017

Kloetzel PM

1

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31 July 2017

publication date

1 March 2001

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Nature Reviews Molecular Cell Biology

31 July 2017

published in

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31 July 2017

volume

2

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31 July 2017

issue

3

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31 July 2017

page(s)

179-187

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Structure and functions of the 20S and 26S proteasomes

31 July 2017

cites work

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7 January 2021

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

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7 January 2021

A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.

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7 January 2021

The base of the proteasome regulatory particle exhibits chaperone-like activity

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7 January 2021

Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome

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7 January 2021

Functional analysis of the proteasome regulatory particle

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7 January 2021

Structure of 20S proteasome from yeast at 2.4 A resolution

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7 January 2021

Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution

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7 January 2021

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

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7 January 2021

Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly

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7 January 2021

Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis

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7 January 2021

The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation

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7 January 2021

Inactivation of a defined active site in the mouse 20S proteasome complex enhances major histocompatibility complex class I antigen presentation of a murine cytomegalovirus protein.

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7 January 2021

MHC ligands and peptide motifs: first listing

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7 January 2021

The three-dimensional structure of peptide-MHC complexes

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7 January 2021

Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast

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7 January 2021

The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses

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7 January 2021

Significance of the rapid degradation of newly synthesized proteins in mammalian cells: a working hypothesis

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7 January 2021

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.

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7 January 2021

Detecting and measuring cotranslational protein degradation in vivo

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7 January 2021

The major substrates for TAP in vivo are derived from newly synthesized proteins

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7 January 2021

The 19S ring-type particles of Drosophila. Cytological and biochemical analysis of their intracellular association and distribution.

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7 January 2021

Degradation of cell proteins and the generation of MHC class I-presented peptides

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7 January 2021

Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor beta subunits

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7 January 2021

20 S proteasomes are assembled via distinct precursor complexes. Processing of LMP2 and LMP7 proproteins takes place in 13-16 S preproteasome complexes

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7 January 2021

Sequence information within proteasomal prosequences mediates efficient integration of beta-subunits into the 20 S proteasome complex

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7 January 2021

Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta 5i) incorporation into 20 S proteasomes

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7 January 2021

The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome

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7 January 2021

Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits

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7 January 2021

Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes

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7 January 2021

Different proteasome subtypes in a single tissue exhibit different enzymatic properties.

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7 January 2021

MHC class I antigen processing of an adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells

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7 January 2021

Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28

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7 January 2021

Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 alpha/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope

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7 January 2021

Structure of the proteasome activator REGalpha (PA28alpha)

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7 January 2021

A role for the proteasome regulator PA28alpha in antigen presentation

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7 January 2021

The proteasome regulator PA28α/β can enhance antigen presentation without affecting 20S proteasome subunit composition

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7 January 2021

Impaired immunoproteasome assembly and immune responses in PA28-/- mice.

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7 January 2021

Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands

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7 January 2021

Double-cleavage production of the CTL epitope by proteasomes and PA28: role of the flanking region

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7 January 2021

Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28.

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7 January 2021

Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis

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7 January 2021

A gated channel into the proteasome core particle

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7 January 2021

The high molecular weight multicatalytic proteinase, macropain, exists in a latent form in human erythrocytes

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7 January 2021

Activation of the multicatalytic proteinase from rat skeletal muscle by fatty acids or sodium dodecyl sulphate

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7 January 2021

The effect of heat shock on 20S/26S proteasomes.

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7 January 2021

Structural basis for the activation of 20S proteasomes by 11S regulators

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7 January 2021

Recognition of the polyubiquitin proteolytic signal

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7 January 2021

Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1.

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7 January 2021

Existence of a molecular ruler in proteasomes suggested by analysis of degradation products

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7 January 2021

Human transporters associated with antigen processing (TAPs) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to T cells

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7 January 2021

Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules

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7 January 2021

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein

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7 January 2021

The sequence alteration associated with a mutational hotspot in p53 protects cells from lysis by cytotoxic T lymphocytes specific for a flanking peptide epitope

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7 January 2021

Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site

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7 January 2021

A Single Residue Exchange Within a Viral CTL Epitope Alters Proteasome-Mediated Degradation Resulting in Lack of Antigen Presentation

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7 January 2021

A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20 S proteasome.

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7 January 2021

Contribution of proline residue for efficient production of MHC class I ligands by proteasomes

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7 January 2021

Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase

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7 January 2021

An algorithm for the prediction of proteasomal cleavages

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7 January 2021

A kinetic model of vertebrate 20S proteasome accounting for the generation of major proteolytic fragments from oligomeric peptide substrates

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7 January 2021

SYFPEITHI: database for MHC ligands and peptide motifs

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7 January 2021

Mechanisms of viral interference with MHC class I antigen processing and presentation

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7 January 2021

Effects on NF-kappa B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome

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7 January 2021

HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteasome alpha-subunit

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7 January 2021

HsN3 proteasomal subunit as a target for human immunodeficiency virus type 1 Nef protein.

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7 January 2021

Regulation of the 26S proteasome by adenovirus E1A

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7 January 2021

HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation

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7 January 2021

Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a

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7 January 2021

Generation and TAP-mediated transport of peptides for major histocompatibility complex class I molecules.

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7 January 2021

Mechanisms of MHC class I--restricted antigen processing

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7 January 2021

The thiol oxidoreductase ERp57 is a component of the MHC class I peptide-loading complex

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7 January 2021

A role for the thiol-dependent reductase ERp57 in the assembly of MHC class I molecules

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7 January 2021

Altered peptidase and viral-specific T cell response in LMP2 mutant mice.

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7 January 2021

MHC class I expression in mice lacking the proteasome subunit LMP-7

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7 January 2021

Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells

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7 January 2021

Identifiers

DOI

10.1038/35056572

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Dimensions Publication ID

31 July 2017

1001569345

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