Binding of flexible and constrained ligands to the Grb2 SH2 domain: structural effects of ligand preorganization (Q34196318)

31 July 2017

title

Binding of flexible and constrained ligands to the Grb2 SH2 domain: structural effects of ligand preorganization (English)

1 reference

31 July 2017

John H Clements

1

1 reference

31 July 2017

John E DeLorbe

series ordinal

2

1 reference

31 July 2017

Aaron P Benfield

series ordinal

3

1 reference

31 July 2017

Stephen F Martin

series ordinal

4

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31 July 2017

publication date

18 September 2010

1 reference

Acta Crystallographica Section D: Biological Crystallography

31 July 2017

published in

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31 July 2017

volume

66

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31 July 2017

issue

Pt 10

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31 July 2017

page(s)

1101-1115

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Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization

31 July 2017

cites work

1 reference

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Structural and energetic aspects of Grb2-SH2 domain-swapping

28 July 2018

1 reference

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The SH2 domain: versatile signaling module and pharmaceutical target

28 July 2018

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28 July 2018

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28 July 2018

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Molecular recognition by SH2 domains

28 July 2018

1 reference

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Specificity and affinity motifs for Grb2 SH2-ligand interactions

28 July 2018

1 reference

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Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor

28 July 2018

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Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding

28 July 2018

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Lowering the entropic barrier for binding conformationally flexible inhibitors to enzymes

28 July 2018

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

28 July 2018

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Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands

28 July 2018

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Thermodynamic and structural analysis of phosphotyrosine polypeptide binding to Grb2-SH2

28 July 2018

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Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode

28 July 2018

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28 July 2018

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28 July 2018

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Stereochemical quality of protein structure coordinates

28 July 2018

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28 July 2018

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Increasing complexity of the Ras signaling pathway

28 July 2018

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Ligand preorganization may be accompanied by entropic penalties in protein-ligand interactions

28 October 2018

1 reference

12 December 2020

Do structurally similar ligands bind in a similar fashion?

1 reference

12 December 2020

Conformational constraint in protein ligand design and the inconsistency of binding entropy

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

10.1107/S0907444910035584

Identifiers

DOI

1 reference

release_uakdpasetngqjmux3qiuc5pbea

31 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/uakdpasetngqjmux3qiuc5pbea

24 November 2022

mapped directly with Wikidata item

PMC publication ID

2954456

1 reference

31 July 2017

1 reference