Impact of cellular metabolism on the biological effects of benzo[a]pyrene and related hydrocarbons (Q34196447)

31 July 2017

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title

Impact of cellular metabolism on the biological effects of benzo[a]pyrene and related hydrocarbons (English)

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31 July 2017

K P Miller

1

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31 July 2017

K S Ramos

series ordinal

2

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31 July 2017

language of work or name

English

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publication date

1 February 2001

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31 July 2017

published in

Drug Metabolism Reviews

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31 July 2017

volume

33

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31 July 2017

issue

1

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31 July 2017

page(s)

1-35

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Benzo-a-pyrene: environmental partitioning and human exposure

31 July 2017

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Different pathways involved in the metabolism of the 7.8- and 9, 10-dihydrodiols of benzo(a)pyrene

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The microsomal metabolism of benzo(a)pyrene phenols

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Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells

21 January 2018

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Alterations of pulmonary benzo[a]pyrene metabolism by reactive oxygen metabolites

21 January 2018

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Oxidative stress to DNA, protein, and antioxidant enzymes (superoxide dismutase and catalase) in rats treated with benzo(a)pyrene.

21 January 2018

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Tumour-initiating activities on mouse skin of dihydrodiols derived from benzo[a]pyrene

21 January 2018

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Phenolic benzo(a)pyrene metabolites are mutagens

21 January 2018

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Characterization of benzo[a]pyrene quinone-induced toxicity to primary cultured bone marrow stromal cells from DBA/2 mice: potential role of mitochondrial dysfunction.

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Action by the lungs on circulating xenobiotic agents, with a case study of physiologically based pharmacokinetic modeling of benzo(a)pyrene disposition

21 January 2018

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Glucuronide conjugation reduces the cytotoxicity but not the mutagenicity of benzo(a)pyrene in the CHO/HGPRT assay

21 January 2018

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The influence of bile on the bioavailability of polynuclear aromatic hydrocarbons from the rat intestine.

21 January 2018

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Analysis of benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line

21 January 2018

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An enzymic analysis of a nuclear envelope fraction

21 January 2018

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Chronic, topical exposure to benzo[a]pyrene induces relatively high steady-state levels of DNA adducts in target tissues and alters kinetics of adduct loss

21 January 2018

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Studies on the metabolism of benzo[a]pyrene and dose-dependent differences in the mutagenic profile of its ultimate carcinogenic metabolite

21 January 2018

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DNA adduct formation by polycyclic aromatic hydrocarbon dihydrodiol epoxides

21 January 2018

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NADPH-Supported and arachidonic acid-supported metabolism of the enantiomers of trans-7,8-dihydrobenzo[a]pyrene-7,8-diol by human liver microsomal samples

21 January 2018

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Differences in mutagenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides

21 January 2018

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Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

21 January 2018

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Benzo[a]pyrene diol epoxide covalently binds to deoxyguanosine and deoxyadenosine in DNA

21 January 2018

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32P-Postlabeling analysis of lipophilic DNA adducts resulting from interaction with (+/-)-3-hydroxy-trans-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo [a]pyrene

21 January 2018

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NAD(P)H:quinone oxidoreductase1 (DT diaphorase) specifically prevents the formation of benzo[a]pyrene quinone-DNA adducts generated by cytochrome P4501A1 and P450 reductase

21 January 2018

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Neutrophils amplify the formation of DNA adducts by benzo[a]pyrene in lung target cells

21 January 2018

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The role of 9-hydroxybenzo(a)pyrene in the microsome mediated binding of benzo(a)pyrene to DNA

21 January 2018

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β-Glucuronidase Catalyzed Hydrolysis of Benzo[ a ]pyrene-3-Glucuronide and Binding to DNA

21 January 2018

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Mutagenicity of quinones: pathways of metabolic activation and detoxification

21 January 2018

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Comparison between in vivo mutagenicity and carcinogenicity in multiple organs by benzo[a]pyrene in the lacZ transgenic mouse (Muta Mouse).

21 January 2018

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Ah receptor signaling pathways

21 January 2018

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Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer

21 January 2018

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A DNA-binding factor specific for xenobiotic responsive elements of P-450c gene exists as a cryptic form in cytoplasm: its possible translocation to nucleus

21 January 2018

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Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene

21 January 2018

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A benzo[a]pyrene-induced cell cycle checkpoint resulting in p53-independent G1 arrest in 3T3 fibroblasts

21 January 2018

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Profiles of antioxidant/electrophile response element (ARE/EpRE) nuclear protein binding and c-Ha-ras transactivation in vascular smooth muscle cells treated with oxidative metabolites of benzo[a]pyrene

21 January 2018

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The rat quinone reductase antioxidant response element. Identification of the nucleotide sequence required for basal and inducible activity and detection of antioxidant response element-binding proteins in hepatoma and non-hepatoma cell lines

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element

21 January 2018

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ARE- and TRE-mediated regulation of gene expression. Response to xenobiotics and antioxidants

21 January 2018

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Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

21 January 2018

1 reference

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Constitutive and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100000138

Activation of antioxidant/electrophile-responsive elements in IMR-32 human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100000138

Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100000138

Depletion of glutathione by benzo(a)pyrene metabolites, ionomycin, thapsigargin, and phorbol myristate in human peripheral blood mononuclear cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100000138

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100000138

Expression of different Jun and Fos proteins during the G0-to-G1 transition in mouse fibroblasts: in vitro and in vivo associations

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

Benzo[a]pyrene- and TCDD-induced alterations in tyrosine phosphorylation and insulin-like growth factor signaling pathways in the MCF-10A human mammary epithelial cell line

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

Modulation by benzo[a]pyrene of epidermal growth factor receptors, cell proliferation, and secretion of human chorionic gonadotropin in human placental cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100000138

Benzo[a]pyrene and other inducers of cytochrome P1-450 inhibit binding of epidermal growth factor to cell surface receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100000138

Oxidative stress oppositely modulates protein tyrosine phosphorylation stimulated by muscarinic G protein-coupled and epidermal growth factor receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100000138

H2O2 is an important mediator of UVB-induced EGF-receptor phosphorylation in cultured keratinocytes

21 January 2018

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Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules.

21 January 2018

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(+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene: a potent skin carcinogen when applied topically to mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100000138

Benzo[a]pyrene 7,8-dihydrodiol is more carcinogenic than benzo[a]pyrene in newborn mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100000138

A comparison of mutational specificity of mutations induced by S9-activated B[a]P and benzo[a]pyrene-7,8-diol-9,10-epoxide at the endogenous aprt gene in CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100000138

The major, N2-dG adduct of (+)-anti-B[a]PDE induces G-->A mutations in a 5'-AGA-3' sequence context.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100000138

Mutational specificity of the (+)-anti-diol epoxide of benzo[a]pyrene in a supF gene of an Escherichia coli plasmid: DNA sequence context influences hotspots, mutagenic specificity and the extent of SOS enhancement of mutagenesis.

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

Mutagenesis by the (+)-anti-diol epoxide of benzo[a]pyrene: what controls mutagenic specificity?

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

Mutagenesis by (+)-anti-B[a]P-N2-Gua, the major adduct of activated benzo[a]pyrene, when studied in an Escherichia coli plasmid using site-directed methods.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100000138

The major, N2-dG adduct of (+)-anti-B[a]PDE shows a dramatically different mutagenic specificity (predominantly, G --> A) in a 5'-CGT-3' sequence context.

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

The pathogenesis of atherosclerosis: a perspective for the 1990s

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

Evidence for a Monoclonal Origin of Human Atherosclerotic Plaques

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

Proliferation and the monoclonal origins of atherosclerotic lesions

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

Modulation of protooncogene expression in rat aortic smooth muscle cells by benzo[a]pyrene

21 January 2018

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Induction of cytochrome CYPIA1 and formation of toxic metabolites of benzo[a]pyrene by rat aorta: a possible role in atherogenesis

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

Kinetics, activation, and induction of aortic mono-oxygenases--biotransformation of benzo[a]pyrene

21 January 2018

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Evidence for roles of radicals in protein oxidation in advanced human atherosclerotic plaque

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

A comparative study on the metabolic activation of 3,4-benzo[a]pyrene to mutagens by aorta smooth muscle cells of rat and rabbit

21 January 2018

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Effects of cigarette smoking on metabolic events in the lung

21 January 2018

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Xenobiotic biotransformation/bioactivation in organogenesis-stage conceptual tissues: implications for embryotoxicity and teratogenesis

21 January 2018

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Reactive oxygen species in developmental toxicity: review and hypothesis

21 January 2018

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Biochemical toxicology of chemical teratogenesis

21 January 2018

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Oxidative damage in chemical teratogenesis

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

A teratologic suppressor role for p53 in benzo(a)pyrene–treated transgenic p53-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

Reproductive toxicity associated with endometrial cell mediated metabolism of benzo[a]pyrene: a combined in vitro, in vivo approach.

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

The murine Ah locus: in utero toxicity and teratogenesis associated with genetic differences in benzo[a]pyrene metabolism

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

The pathological effects of the intraperitoneal injection of 3:4-benzpyrene into rats and mice

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

Interference with Protein Kinase C-Related Signal Transduction in Vascular Smooth Muscle Cells by Benzo[a]pyrene

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

The Induction of Proliferative Vascular Smooth Muscle Cell Phenotypes by Benzo(a)pyrene Is Characterized by Up-Regulation of Inositol Phospholipid Metabolism and c-Ha-ras Gene Expression

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

Excisability and persistence of benzo(a)pyrene DNA adducts in epithelioid human lung cells

21 January 2018

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Comprehensive Analysis of Proteins Which Interact with the Antioxidant Responsive Element: Correlation of ARE-BP-1 with the Chemoprotective Induction Response

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100000138

21 January 2018

Identifiers

DOI

10.1081/DMR-100000138

1 reference

31 July 2017

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