Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer (Q34204078)

31 July 2017

Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer (English)

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31 July 2017

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Kai-Hsiung Chang

1

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31 July 2017

Rui Li

2

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31 July 2017

Mahboubeh Papari-Zareei

3

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31 July 2017

Lori Watumull

4

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31 July 2017

Yan Daniel Zhao

5

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31 July 2017

Richard J Auchus

6

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31 July 2017

Nima Sharifi

7

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31 July 2017

language of work or name

English

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publication date

27 July 2011

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31 July 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

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published in

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31 July 2017

108

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31 July 2017

13728-13733

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31 July 2017

33

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Assessment of steroidogenic pathways that do not require testosterone as intermediate

31 July 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Abiraterone and increased survival in metastatic prostate cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

"Getting from here to there"--mechanisms and limitations to the activation of the androgen receptor in castration-resistant prostate cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

3beta-hydroxysteroid dehydrogenase is a possible pharmacological target in the treatment of castration-resistant prostate cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Phase II study of Dutasteride for recurrent prostate cancer during androgen deprivation therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Androgen biosynthetic pathways in the human prostate

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Pre-receptor regulation of the androgen receptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Hierarchical organization of prostate cancer cells in xenograft tumors: the CD44+alpha2beta1+ cell population is enriched in tumor-initiating cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Androgen deprivation therapy for prostate cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Steroid 5 alpha-reductase: two genes/two enzymes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase from placenta: expression in nonsteroidogenic cells of a protein that catalyzes the dehydrogenation/isomerization of C21 and C19 steroids

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Finasteride, an inhibitor of 5 alpha-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Testosterone and 5 alpha-dihydrotestosterone interact differently with the androgen receptor to enhance transcription of the MMTV-CAT reporter gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

DHT Concentrations in Human Prostate Cancer Tissue*

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3158152

Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1107898108

Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1107898108

17β-Hydroxysteroid dehydrogenase 3 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1107898108

Steroid 5alpha-reductase isozymes I and II in recurrent prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1107898108

Benefits of combination therapy with flutamide in patients relapsing after castration

21 January 2018

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12 December 2020

The Intranuclear Binding of Testosterone and 5α-Androstan-17β-ol-3-one by Rat Prostate

1 reference

12 December 2020

Characterization of Chinese hamster ovary cell lines expressing human steroid 5 alpha-reductase isozymes

1 reference

12 December 2020

19-Nor-10-azasteroids, a New Class of Steroid 5α-Reductase Inhibitors. 2.1X-ray Structure, Molecular Modeling, Conformational Analysis of 19-Nor-10-azasteroids and Comparison with 4-Azasteroids and 6-Azasteroids

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1107898108

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31 July 2017

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31 July 2017

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