Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner (Q34205103)

31 July 2017

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner (English)

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31 July 2017

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7

Domenico Accili

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31 July 2017

5

Gerald I Shulman

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31 July 2017

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Varman T Samuel

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31 July 2017

4

Andreas L Birkenfeld

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31 July 2017

Utpal B Pajvani

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31 July 2017

Carrie J Shawber

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2

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31 July 2017

Jan Kitajewski

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31 July 2017

language of work or name

English

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publication date

31 July 2011

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31 July 2017

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31 July 2017

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31 July 2017

961-967

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https://scigraph.springernature.com/pub.10.1038/nm.2378

31 July 2017

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cites work

FoxOs function synergistically to promote glucose production

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Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Direct inhibition of the NOTCH transcription factor complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Alzheimer's disease and Notch signaling.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Notch signaling: the core pathway and its posttranslational regulation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Notch inhibitors as a new tool in the war on cancer: a pathway to watch

28 July 2018

1 reference

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gamma-Secretase in biology and medicine

28 July 2018

1 reference

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Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Notch signaling regulates tumor angiogenesis by diverse mechanisms

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5'-AMP-activated protein kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Functional silencing of hepatic microsomal glucose-6-phosphatase gene expression in vivo by adenovirus-mediated delivery of short hairpin RNA.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Effects of adenovirus-mediated liver-selective overexpression of protein tyrosine phosphatase-1b on insulin sensitivity in vivo

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Notch signaling is essential for vascular morphogenesis in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Calcium depletion dissociates and activates heterodimeric notch receptors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Disruption of the mouse RBP-J kappa gene results in early embryonic death

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387563

Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic

28 July 2018

1 reference

Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy

21 January 2018

1 reference

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.

21 January 2018

1 reference

Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.

21 January 2018

1 reference

Notch signaling controls liver development by regulating biliary differentiation

21 January 2018

1 reference

Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage.

21 January 2018

1 reference

A Foxo/Notch pathway controls myogenic differentiation and fiber type specification

21 January 2018

1 reference

Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.

21 January 2018

1 reference

The forkhead transcription factor Foxo1 regulates adipocyte differentiation

21 January 2018

1 reference

Cell biology. Selective insulin sensitizers

21 January 2018

1 reference

12 December 2020

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

1 reference

12 December 2020

Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas

1 reference

12 December 2020

A garden of Notch-ly delights

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.2378

1 reference

release_kvkpbymnn5frpnuwspg4qs5rvq

31 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/kvkpbymnn5frpnuwspg4qs5rvq

24 November 2022

mapped directly with Wikidata item

PMCID

3387563

1 reference

31 July 2017

1 reference