ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis (Q34205901)

31 July 2017

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title

ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis (English)

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31 July 2017

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Priyanka Verma

1

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PubMed ID

21815191

31 July 2017

Krishna Dalal

series ordinal

2

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31 July 2017

1 December 2011

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Journal of Cellular Biochemistry

31 July 2017

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31 July 2017

112

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31 July 2017

12

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31 July 2017

3507-3514

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Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

31 July 2017

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A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms

21 January 2018

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The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

21 January 2018

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Effects of glucosamine and chondroitin sulfate on bovine cartilage explants under long-term culture conditions.

21 January 2018

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Metalloproteinases: their role in arthritis and potential as therapeutic targets

21 January 2018

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ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage

21 January 2018

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Risk factors for the incidence and progression of radiographic knee osteoarthritis

21 January 2018

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Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.

21 January 2018

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Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis

21 January 2018

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The futility of current approaches to chondroprotection

21 January 2018

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Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites

21 January 2018

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Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity

21 January 2018

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Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation

21 January 2018

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Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.

21 January 2018

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Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice

21 January 2018

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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

21 January 2018

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Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration

21 January 2018

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Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors.

21 January 2018

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Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions

21 January 2018

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ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family

21 January 2018

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Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing

21 January 2018

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Expression profiling of metalloproteinases and their inhibitors in cartilage

21 January 2018

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The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction

21 January 2018

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ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan

21 January 2018

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The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential

21 January 2018

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ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein

21 January 2018

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Thyroid hormone enhances aggrecanase-2/ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage.

21 January 2018

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Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage

21 January 2018

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Metalloproteases and inhibitors in arthritic diseases

21 January 2018

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Osteoarthritis of the knee joint: an eight year prospective study

21 January 2018

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Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member

21 January 2018

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Effects of covalently attached chondroitin sulfate on aggrecan cleavage by ADAMTS-4 and MMP-13.

21 January 2018

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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

21 January 2018

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Aggrecanases and cartilage matrix degradation

21 January 2018

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The ADAMTS metalloproteinases

21 January 2018

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Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system

21 January 2018

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ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors

21 January 2018

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Variations in aggrecan structure modulate its susceptibility to aggrecanases

21 January 2018

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Leech thrombin inhibitors

21 January 2018

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The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

21 January 2018

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Discovery of (1S,2R,3R)-2,3-dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: novel and highly selective aggrecanase inhibitors

21 January 2018

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Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1

21 January 2018

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Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

21 January 2018

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Radiological progression of osteoarthritis: an 11 year follow up study of the knee

21 January 2018

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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

21 January 2018

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Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

21 January 2018

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Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)

21 January 2018

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The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage

21 January 2018

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Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors

21 January 2018

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Roles of aggrecan, a large chondroitin sulfate proteoglycan, in cartilage structure and function.

21 January 2018

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Expression and regulation of aggrecanase in arthritis: the role of TGF-beta

21 January 2018

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Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors

21 January 2018

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Potent P1' biphenylmethyl substituted aggrecanase inhibitors

21 January 2018

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Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption

21 January 2018

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Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.23298

1 reference

31 July 2017

1 reference

PubMed ID

21815191