Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production (Q34212784)

31 July 2017

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production (English)

1 reference

31 July 2017

reactive oxygen species

1 reference

0 references

1 reference

10

Nils-Göran Larsson

1 reference

31 July 2017

Anna Wredenberg

3

1 reference

ORCID Public Data File 2021

Ivan Khvorostov

6

object named as

Ivan Khvorostov

1 reference

31 July 2017

8

Rolf Wibom

1 reference

31 July 2017

Aleksandra Trifunovic

1

1 reference

31 July 2017

Anna Hansson

2

1 reference

31 July 2017

Anja T Rovio

4

1 reference

31 July 2017

Eric Dufour

5

1 reference

31 July 2017

Johannes N Spelbrink

7

1 reference

31 July 2017

Howard T Jacobs

9

1 reference

31 July 2017

language of work or name

English

0 references

publication date

6 December 2005

1 reference

Proceedings of the National Academy of Sciences of the United States of America

31 July 2017

1 reference

31 July 2017

102

1 reference

31 July 2017

50

1 reference

31 July 2017

17993-17998

1 reference

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

31 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Extension of murine life span by overexpression of catalase targeted to mitochondria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Mitochondria, oxidants, and aging

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production-DNA damage mechanism?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Premature ageing in mice expressing defective mitochondrial DNA polymerase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Aging: a theory based on free radical and radiation chemistry

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Effects of Overexpression of Copper-Zinc and Manganese Superoxide Dismutases, Catalase, and Thioredoxin Reductase Genes on Longevity in Drosophila melanogaster

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Oxidant signals and oxidative stress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

5 July 2018

Mitochondria and ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

A causal link between respiration and senescence in Podospora anserina

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

The p66shc adaptor protein controls oxidative stress response and life span in mammals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Mitochondrial disease in superoxide dismutase 2 mutant mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

The biologic clock: the mitochondria?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Relationship between life expectancy, endogenous antioxidants and products of oxygen free radical reactions in the housefly, Musca domestica

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Establishment of mouse embryo cells in vitro. Relationship of DNA synthesis, senescence and malignant transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Antioxidants prolong life span and inhibit the senescence-dependent accumulation of fluorescent pigment (lipofuscin) in clones, of Podospora anserina

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Isolation of biogenetically competent mitochondria from mammalian tissues and cultured cells

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508886102

Mitochondrial transcription factor A regulates mtDNA copy number in mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508886102

Measurement of ATP production and respiratory chain enzyme activities in mitochondria isolated from small muscle biopsy samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508886102

Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508886102

Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508886102

No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508886102

Methionine-induced alterations in the life span, antioxidant enzymes, and peroxide levels in aging Zaprionus paravittiger (Diptera).

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508886102

Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508886102

DAF-16 target genes that control C. elegans life-span and metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508886102

Extended life-span conferred by cotransporter gene mutations in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0508886102

Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

The inactivation of Fe-S cluster containing hydro-lyases by superoxide.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1312403

Biochemical and molecular investigations in respiratory chain deficiencies

28 October 2018

1 reference

12 December 2020

CuZn-superoxide dismutase transgenic mice: no effect on longevity, locomotor activity and 3H-mazindol and 3H-spiperone binding over 19 months

1 reference

12 December 2020

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

1 reference

12 December 2020

Age-dependent structural changes in the myocardium of rats. A quantitative light- and electron-microscopic study on the right and left chamber wall

1 reference

12 December 2020

Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0508886102

1 reference

31 July 2017

0 references

1 reference

31 July 2017

1 reference