The mechanism of formation of N-formylkynurenine by heme dioxygenases. (Q34213607)

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12 February 2020

title

The mechanism of formation of N-formylkynurenine by heme dioxygenases (English)

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12 February 2020

5

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Sandeep Handa

9

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Emma L. Raven

10

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Christopher G Mowat

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12 February 2020

author name string

Jaswir Basran

1

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12 February 2020

Igor Efimov

2

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12 February 2020

Nishma Chauhan

3

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Sarah J Thackray

4

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Graham Eaton

6

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Gerry A Griffith

7

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language of work or name

English

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publication date

19 September 2011

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Journal of the American Chemical Society

12 February 2020

published in

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volume

133

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issue

40

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page(s)

16251-16257

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Structure and reaction mechanism in the heme dioxygenases.

12 February 2020

cites work

1 reference

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The ternary complex of PrnB (the second enzyme in the pyrrolnitrin biosynthesis pathway), tryptophan, and cyanide yields new mechanistic insights into the indolamine dioxygenase superfamily

5 July 2018

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The first step of the dioxygenation reaction carried out by tryptophan dioxygenase and indoleamine 2,3-dioxygenase as revealed by quantum mechanical/molecular mechanical studies

5 July 2018

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Probing the ternary complexes of indoleamine and tryptophan 2,3-dioxygenases by cryoreduction EPR and ENDOR spectroscopy

5 July 2018

1 reference

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Rational design of indoleamine 2,3-dioxygenase inhibitors

5 July 2018

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Evidence for a ferryl intermediate in a heme-based dioxygenase.

5 July 2018

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Reassessment of the reaction mechanism in the heme dioxygenases.

5 July 2018

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Nature of the Fe-O2 bonding in oxy-myoglobin: effect of the protein

5 July 2018

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Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding

5 July 2018

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Density functional theory study on a missing piece in understanding of heme chemistry: the reaction mechanism for indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase

5 July 2018

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Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer disease

5 July 2018

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A kinetic, spectroscopic, and redox study of human tryptophan 2,3-dioxygenase.

5 July 2018

1 reference

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Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape.

5 July 2018

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Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase

5 July 2018

1 reference

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A valid model for the mechanism of oxidation of tryptophan to formylkynurenine-25 years later

5 July 2018

1 reference

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Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase

5 July 2018

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Redox and spectroscopic properties of human indoleamine 2,3-dioxygenase and a His303Ala variant: implications for catalysis

5 July 2018

1 reference

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Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes.

5 July 2018

1 reference

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The heme environment of recombinant human indoleamine 2,3-dioxygenase. Structural properties and substrate-ligand interactions

5 July 2018

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Heme-Containing Oxygenases

5 July 2018

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Mechanisms of two- and four-electron oxidations catalyzed by some metalloenzymes

5 July 2018

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1-Methyl-DL-tryptophan, beta-(3-benzofuranyl)-DL-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-DL-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase

5 July 2018

1 reference

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Indoleamine 2,3-dioxygenase: incorporation of 18O2-- and 18O2 into the reaction products

5 July 2018

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Can ferric-superoxide act as a potential oxidant in P450(cam)? QM/MM investigation of hydroxylation, epoxidation, and sulfoxidation.

5 July 2018

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ONIOM study on a missing piece in our understanding of heme chemistry: bacterial tryptophan 2,3-dioxygenase with dual oxidants.

28 October 2018

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Characterization of O(2) ((1)delta(g))-derived oxidation products of tryptophan: a combination of tandem mass spectrometry analyses and isotopic labeling studies.

28 October 2018

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The role of serine 167 in human indoleamine 2,3-dioxygenase: a comparison with tryptophan 2,3-dioxygenase

28 October 2018

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Selective dehydrogenation/oxygenation of 3-methylindole by cytochrome p450 enzymes

28 October 2018

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Evidence supporting the formation of 2,3-epoxy-3-methylindoline: a reactive intermediate of the pneumotoxin 3-methylindole

28 October 2018

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On-line HPLC-tandem mass spectrometry analysis of contaminants of l-tryptophan associated with the onset of the eosinophilia-myalgia syndrome

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21892828

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Studies on oxygenases; enzymatic formation of kynurenine from tryptophan

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21892828

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JA207066Z

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21892828%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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12 February 2020

PubMed publication ID

21892828

1 reference